Bioelectrochemistry
Department of Bionics and Experimental Medical Biology, Poznan University of Medical Sciences, Parkowa 2, 60-775 Poznań, Poland.
Published: April 2023
The dielectric properties of the non-glycated and in vitro methylglyoxal-glycated cornea of the rabbit eye were tested in the frequency range of 200 Hz to 100 kHz of the electric field and at temperatures of 25 to 140 °C. The denaturation temperature (T) for the non-glycated cornea and the non-enzymatically glycated cornea are approximately 45 and 55 °C, respectively. The mechanism of proton conduction up to T in a glycated cornea requires more energy, i.e. more than twice the activation energy (ΔH) than in non-glycated tissue. The dielectric spectra for both examined tissues showed the same characteristic frequency of about 7 kHz assigned to the orientation relaxation time of the polar side groups inside the corneal stroma. These results may be useful in the surgical treatment of the cornea using conductive keratoplasty and in tissue engineering for clinical applications to regenerate this tissue. The medical use of these physico-biological techniques is important because the human cornea protects all eye tissues from various environmental factors.
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http://dx.doi.org/10.1016/j.bioelechem.2022.108333 | DOI Listing |
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