AI Article Synopsis
- Fifteen rhenium(I) tricarbonyl complexes were created using a mixed ligand approach, achieving an average yield of 84%.
- The complexes were characterized with various spectroscopy techniques, revealing a trend in carbonyl stretching frequencies affected by the presence of fluorine atoms in the ligand.
- Biological tests showed one complex, fac-[Re(Pico)(CO)(HO)], to be toxic, providing useful data for potential drug toxicity controls.
Article Abstract
Fifteen rhenium(I) tricarbonyl complexes of the form fac-[Re(N,O')(CO)(X)], where N,O'-bidentate ligand = 2-picolinic acid (Pico); 3,5-difluoropyridine-2-carboxylic acid (Dfpc); 3-trifluoromethyl-pyridine-2-carboxylic acid (Tfpc) and X = HO; pyrazole (Pz); pyridine (Py); imidazole (Im); and methanol (CHOH) were synthesized using the '2 + 1' mixed ligand approach with an average yield of 84%. The complexes were characterized using the following spectroscopic techniques: IR, H and C NMR, UV/Vis, and single-crystal X-ray diffraction. The effect of the fluorine atoms on the backbone of the N,O'-bidentate ligand was investigated and a trend was noticed in the carbonyl stretching frequencies: with Pico < Tfpc < Dfpc. The in vitro biological screening on Vero (healthy mammalian), HeLa (cervical carcinoma) and A549 (lung cancer) cells revealed one toxic complex, fac-[Re(Pico)(CO)(HO)], with respective LC values of 9.0 ± 0.9, 15.8 ± 4.9 (SI = 0.570) and 20.9 ± 0.8 (SI = 0.430) μg/mL. As a result, it can be used as a positive control drug of toxicity.
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| http://dx.doi.org/10.1007/s00775-022-01971-2 | DOI Listing |
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