AI Article Synopsis
- Antibiotic-resistant bacteria are becoming a major global problem, highlighting the need for new antibiotics.
- Bacillus species, especially within the B. cereus group, produce bacteriocins—small peptides with strong antibacterial properties that are stable under various conditions.
- This study isolated and compared five bacteriocins from three related Bacillus species and found significant differences in their molecular mass and antibacterial effectiveness, reinforcing that bacteriocins can be linked to their specific Bacillus species of origin.
Article Abstract
The antibiotic-resistant bacteria are emerging as a great threat worldwide. For this reason it is important to develop new antibiotic substances. Bacillus is considered as a factory of a wide range of chemical compounds with a variety of activities. Among these substances are bacteriocins which are small peptides showing stability in a wide range of pH and temperatures and having a potent antibacterial activity. Bacillus species can be grouped into families such as B. cereus group based on their genetic similarity. It can be helpful to study the bacteriocins presented in these related species identifying the differences and similarities between them to relate the presence of a given bacteriocin with the producer specie. The aim of this study was to isolate the bacteriocins from three related species of B. cereus group such as B. mycoides, B. weihenstephanensis and B. toyonensis and compare among them and with the bacteriocins isolated from B. velezensis. Besides it was analyzed the bactericidal activity of each isolated bacteriocin. Five different bacteriocins of similar molecular mass and specific against foodborne pathogens were isolated from three Bacillus species related to B. cereus group, that were quite different both in molecular mass and bactericidal activity from that was isolated from B. velezensis. The results indicated that bacteriocins can be distinguished according to Bacillus specie from it has been isolated.
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