BioBridge Prosthesis Failure After a Ravitch Repair for Pectus Excavatum.

Ann Thorac Surg

Department of Cardiovascular and Thoracic Surgery, Mayo Clinic Arizona, 5777 E Mayo Blvd, Phoenix, AZ 85054. Electronic address:

Published: July 2023

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http://dx.doi.org/10.1016/j.athoracsur.2022.11.020DOI Listing

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BioBridge Prosthesis Failure After a Ravitch Repair for Pectus Excavatum.

Ann Thorac Surg

July 2023

Department of Cardiovascular and Thoracic Surgery, Mayo Clinic Arizona, 5777 E Mayo Blvd, Phoenix, AZ 85054. Electronic address:

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Department of Thoracic Medicine and Surgery, Temple University Hospital, Philadelphia, Pennsylvania; Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania. Electronic address:

Chest wall reconstruction presents a challenging surgical problem with no universally recognized gold standard for the procedure. Various prosthetic and bioprosthetic materials exist for use in chest wall reconstruction, with bioprosthetic materials offering significant advantages in the case of a preoperatively infected surgical field. Here we present a case of the absorbable BioBridge system (Acute Innovations, Hillsboro, OR) used for chest well reconstruction and describe a novel complication of structural failure of the BioBridge plate, involving fracturing of the prosthesis with wound erosion, ultimately requiring reoperation and removal of the device.

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Biobridge: An Outlook on Translational Bioinks for 3D Bioprinting.

Adv Sci (Weinh)

January 2022

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3D-bioprinting (3DBP) possesses several elements necessary to overcome the deficiencies of conventional tissue engineering, such as defining tissue shape a priori, and serves as a bridge to clinical translation. This transformative potential of 3DBP hinges on the development of the next generation of bioinks that possess attributes for clinical use. Toward this end, in addition to physicochemical characteristics essential for printing, bioinks need to possess proregenerative attributes, while enabling printing of stable structures with a defined biological function that survives implantation and evolves in vivo into functional tissue.

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Background: Treatment of secondary lymphedema remains challenging, with suboptimal rates of edema reduction following physiologic procedures (i.e., lymphaticovenous anastomosis and vascularized lymph node transfer).

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Background: We tested our hypothesis that implantation of aligned nanofibrillar collagen scaffolds (BioBridge™) can both prevent and reduce established lymphedema in the rat lymphedema model. Our authors report clinical cases that demonstrate new lymphatic formation guided by BioBridge™ as seen by near-infrared (NIR) fluoroscopy and magnetic resonance (MR) lymphography.

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