Paraptosis is the programmed cell death pathway that leads to cellular necrosis. Manystudies have shown that prolonged paraptosis activation improves tumorimmunogenicity; this treatment reproduces the vaccinating effects of mM-CSFtransduced cells. In this short communication, we want to highlight the paraptosisprocess as a valuable strategy for clinical immunotherapy against cancer.
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Amplifying Ca overload by engineered biomaterials for synergistic cancer therapy.
Biomaterials
May 2025
Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China; Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, 310058, China. Electronic address:
Ca overload is one of the most widely causes of inducing apoptosis, pyroptosis, immunogenic cell death, autophagy, paraptosis, necroptosis, and calcification of tumor cells, and has become the most valuable therapeutic strategy in the field of cancer treatment. Nevertheless, several challenges remain in translating Ca overload-mediated therapeutic strategies into clinical applications, such as the precise control of Ca dynamics, specificity of Ca homeostasis dysregulation, as well as comprehensive mechanisms of Ca regulation. Given this, we comprehensively reviewed the Ca-driven intracellular signaling pathways and the application of Ca-based biomaterials (such as CaCO-, CaP-, CaO-, CaSi-, CaF-, and CaH-) in mediating cancer diagnosis, treatment, and immunotherapy.
View Article and Find Full Text PDFParaptosis-A Distinct Pathway to Cell Death.
Int J Mol Sci
October 2024
Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, Immunology, and Infectious Diseases, University Hospital Regensburg, 93053 Regensburg, Germany.
Cell death is a critical biological process necessary for development, tissue maintenance, and defense against diseases. To date, more than 20 forms of cell death have been identified, each defined by unique molecular pathways. Understanding these different forms of cell death is essential for investigating the pathogenesis of diseases such as cancer, neurodegenerative disorders, and autoimmune conditions and developing appropriate therapies.
View Article and Find Full Text PDFEudesmane-guaiane sesquiterpenoid dimers from Aucklandia costus trigger paraptosis-like cell death via ROS accumulation and MAPK hyperactivation.
Chin J Nat Med
November 2024
State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Yunnan Characteristic Plant Extraction Laboratory, Kunming 650106, China. Electronic address:
Article Synopsis
- Three novel compounds, auckcostusolides A-C, were extracted from Aucklandia costus leaves and their structures were analyzed using advanced spectroscopic techniques and X-ray diffraction.
- Compounds 1 and 2 have the same basic structure but different configurations, a result of distinct chemical processes during their formation.
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Exploring paraptosis as a therapeutic approach in cancer treatment.
J Biomed Sci
November 2024
Center for Molecular Medicine, China Medical University Hospital, Taichung, 406040, Taiwan.
A variety of cell death pathways play critical roles in the onset and progression of multiple diseases. Paraptosis, a unique form of programmed cell death, has gained significant attention in recent years. Unlike apoptosis and necrosis, paraptosis is characterized by cytoplasmic vacuolization, swelling of the endoplasmic reticulum and mitochondria, and the absence of caspase activation.
View Article and Find Full Text PDFActivation of autophagy, paraptosis, and ferroptosis by micheliolide through modulation of the MAPK signaling pathway in pancreatic and colon tumor cells.
Pathol Res Pract
November 2024
Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea. Electronic address:
Micheliolide (MCL), a naturally occurring sesquiterpene lactone, has demonstrated significant anticancer properties through the induction of various programmed cell death mechanisms. This study aimed to explore MCL's effects on autophagy, paraptosis, and ferroptosis in pancreatic and colon cancer cells, along with its modulation of the MAPK signaling pathway. MCL was found to substantially suppress cell viability in these cancer cells, particularly in MIA PaCa-2 and HT-29 cell lines.
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