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Uncovering immune cell-associated genes in breast cancer: based on summary data-based Mendelian randomized analysis and colocalization study.
Breast Cancer Res
November 2024
Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
Background: Breast cancer, which is the most prevalent form of cancer among women globally, encompasses various subtypes that demand distinct treatment approaches. The tumor microenvironment and immune response are of crucial significance in the development and progression of breast cancer. Nevertheless, there has been scant evidence concerning the genes within breast cancer - specific immune cells.
View Article and Find Full Text PDFThe alleviative effects of canagliflozin on imiquimod-induced mouse model of psoriasis-like inflammation.
Naunyn Schmiedebergs Arch Pharmacol
September 2024
College of Pharmacy, Al-Mustaqbal University, Babylon, Hillah, 51001, Iraq.
Psoriasis is a life-long immune-mediated dermatosis with thickened, reddish, and flaky skin patches. Canagliflozin is a gliflozin antidiabetic with non-classical remarkable antioxidative, anti-inflammatory, anti-proliferative, and immune-modulating effects. The aim of this study is to examine the probable effects of topical canagliflozin on a mouse model of imiquimod-provoked psoriasis-like dermatitis.
View Article and Find Full Text PDFA Cross-Sectional Study of Congenital Adrenal Hyperplasia.
Cureus
June 2024
Pediatrics Department, Abderrahim Harouchi Mother-Child Hospital, Ibn Rochd University Hospital, Casablanca, MAR.
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- * A study at Abderrahim Harrouchi Children's Hospital analyzed 184 CAH cases over 11 years, finding that most diagnoses occurred early (median age 1.5 months) and that a high percentage of families reported consanguinity and previous fatalities related to the condition.
- * The most common form of CAH was the classic type (72%), with the majority showing 21-hydroxylase deficiency, and 40.7% of affected children required
Celiac disease (CD), a gluten-related disease, is a multi-system rare disorder mainly involving the gastrointestinal tract. The clinical signs of CD are exceedingly heterogeneous, which increases the difficulty of clinical differential diagnosis. Neurological manifestations are one of the non-classical CD symptoms.
View Article and Find Full Text PDFArticle Synopsis
- Racial and ethnic disparities in lung cancer outcomes are recognized, prompting a study to analyze immune system factors in Black and White patients receiving immunotherapy.
- The research involved 187 non-small cell lung cancer patients, finding notable differences in immune parameters: Black patients showed lower levels of specific cytokines but higher levels of several other cytokines and immune cells compared to White patients.
- These findings highlight significant immune system differences between the two groups, suggesting a need for further investigation into the causes and implications of these disparities.
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