AI Article Synopsis
- Glioblastoma (GBM) is a highly lethal brain cancer, primarily because it often recurs in forms that resist treatment.
- Recent research shows that GBM tumors consist of diverse cell populations that have adapted from initial genetic mutations and maintain some brain cell characteristics, allowing them to evade therapies.
- To improve GBM treatment, it’s crucial to develop new strategies that limit the tumor’s ability to change and adapt.
Article Abstract
Glioblastoma (GBM) remains the most lethal primary brain cancer largely due to recurrence of treatment-resistant disease. Current therapies are ultimately ineffective as GBM tumour cells adapt their identity to escape treatment. Recent advances in single-cell epigenetics and transcriptomics highlight heterogeneous cell populations in GBM tumours originating from unique cancerous genetic aberrations. However, they also suggest that tumour cells conserve molecular properties of parent neuronal cells, with their permissive epigenetic profiles enabling them to morph along a finite number of reprogramming routes to evade treatment. Here, we review the known tumourigenic, neurodevelopmental and brain-injury boundaries of GBM plasticity, and propose that effective treatment of GBM requires the addition of therapeutics that restrain GBM plasticity.
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| http://dx.doi.org/10.1016/j.trecan.2022.10.010 | DOI Listing |
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