Clinical trials evaluating desensitising agents. Some design and analysis issues.

Introduction: The purpose of this short communication is to draw attention to an efficient design for trials to evaluate desensitising agents, and an appropriate statistical analysis.

Methods: Two recent sensitivity trials conducted by the Bristol Dental School Clinical Trials Group are reviewed.

Results: The methodology used was effective to establish efficacy of the products evaluated.

Conclusions: This methodology is recommended for wider use.

Clinical Significance: Effective clinical trial methodology enables establishment of efficacy of desensitising products leading to patient benefit.