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Efficient calcium fumarate overproduction from xylose and corncob-derived xylose by engineered strains of Aureobasidium pullulans var. Aubasidani DH177.
Microb Cell Fact
December 2024
College of Marine Life Sciences, Ocean University of China, Yushan Road, No. 5, Qingdao, China.
Article Synopsis
- Xylose, derived from lignocellulose, is a crucial renewable resource for producing valuable bioproducts like fumaric acid; optimizing its conversion is essential.
- The study identified a genetically modified strain (TKL-4) of A. pullulans that effectively uses xylose and corncob-derived xylose to produce calcium fumarate, demonstrating higher yields compared to glucose.
- The TKL-4 strain achieved impressive fermentation results, generating up to 88.5 g/L of calcium fumarate from xylose during a 10-liter fermentation process, showcasing its potential for eco-friendly bioproduct development.
Cardiac Urea Cycle Activation by Time-Restricted Feeding Protects Against Pressure Overload-Induced Heart Failure.
Adv Sci (Weinh)
December 2024
Key Laboratory of Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Heart failure is a leading cause of mortality worldwide, necessitating the development of novel therapeutic and lifestyle interventions. Recent studies highlight a potential role of time-restricted feeding (TRF) in the prevention and treatment of cardiac diseases. Here, it is found that TRF protected against heart failure at different stages in mice.
View Article and Find Full Text PDFArabidopsis thaliana argininosuccinate lyase structure uncovers the role of serine as the catalytic base.
J Struct Biol
December 2024
Institute of Molecular and Industrial Biotechnology, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Poland. Electronic address:
Arginine is an important amino acid in plants, as it not only plays a structural role and serves as nitrogen storage but is also a precursor for various molecules, including polyamines and proline. Arginine is produced by argininosuccinate lyase (ASL) which catalyzes the cleavage of argininosuccinate to arginine and fumarate. ASL belongs to the fumarate lyase family and while many members of this family were well-characterized, little is known about plant ASLs.
View Article and Find Full Text PDFEnhanced anti-cancer efficacy of arginine deaminase expressed by tumor-seeking Salmonella Gallinarum.
Oncogene
November 2024
Department of Microbiology, Chonnam National University Medical School, Gwangju, 61468, Korea.
Amino acid deprivation, particularly of nonessential amino acids that can be synthesized by normal cells but not by cancer cells with specific defects in the biosynthesis pathway, has emerged as a potential strategy in cancer therapeutics. In normal cells, arginine is synthesized from citrulline in two steps via two enzymes: argininosuccinate synthetase (ASS1) and argininosuccinate lyase. Several cancer cells exhibit arginine auxotrophy due to the loss or down-regulation of ASS1.
View Article and Find Full Text PDFFatal consequences of limited health literacy in a patient with a rare metabolic disease.
Mol Genet Metab Rep
August 2024
McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA.
A Black young adult female diagnosed with argininosuccinate lyase deficiency at 6 months of age encountered significant barriers to care for the first 16 years of her life due to socioeconomic factors and parental neglect. Once in the care of her paternal grandmother, she received appropriate treatment with a nitrogen scavenger, amino acid supplementation, and a low-protein diet. However, due to repeated hyperammonemic crises early in her life, she was minimally communicative and unable to perform activities of daily living.
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