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Tumour cell heterogeneity in triple-negative breast cancer cells affects response to cisplatin, but not doxorubicin. | LitMetric

Tumour cell heterogeneity in triple-negative breast cancer cells affects response to cisplatin, but not doxorubicin.

J Inorg Biochem

School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia; Sydney Analytical, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address:

Published: February 2023

Tumour cell heterogeneity affects cisplatin but not doxorubicin cytotoxicity in two phenotypes of the triple-negative breast cancer (TNBC) cell line, MDA-MB-231. A mesenchymal MDA-MB-231 phenotype was three times less sensitive to cisplatin than an epithelial-type phenotype from the same cell line, which has important implications in the success of TNBC chemotherapies.

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http://dx.doi.org/10.1016/j.jinorgbio.2022.112082DOI Listing

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