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Pituitary Volumes Are Reduced in Patients With Alcohol Use Disorder. | LitMetric

AI Article Synopsis

  • The study aimed to investigate the difference in pituitary gland volumes between individuals with alcohol use disorder and healthy controls.
  • The research involved 15 patients diagnosed with alcohol use disorder and 17 healthy participants, measuring their pituitary gland volumes.
  • Results showed that the pituitary gland volume was significantly smaller in patients with alcohol use disorder (58.02 mm³) compared to healthy controls (83.08 mm³), although the study had limitations like a small sample size and lack of adjustments for medication or mental health conditions.

Article Abstract

Aims: To determine whether there is a difference in pituitary gland volumes in patients with alcohol use disorder compared to healthy people.

Methods: The subjects included in the study consisted of 15 individuals who met the criteria for alcohol use disorder according to the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM 5) diagnostic criteria based on the Structured Clinical Interview for DSM 5 and were admitted to Firat University School of Medicine, Department of Psychiatry, or were hospitalized, and 17 healthy controls. The volumes of pituitary were measured in subjects.

Results: Absolute pituitary gland volumes of patients with alcohol use disorder and healthy controls were compared in the analysis performed using the independent samples t-test. The mean volume of the patient group was significantly smaller than the healthy controls (58.02 ± 7.24 mm3 in patients with alcohol use disorder vs. 83.08 ± 12.11 mm3, P < 0.01), a difference which persisted after controlling for age, gender and total brain size.

Conclusions: Patients with alcohol use disorder in this study had smaller pituitary gland volumes compared to those of healthy control subjects. However, this study has limitations including small sample size and not adjusting for previous or current medication use or current anxiety and depression.

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Source
http://dx.doi.org/10.1093/alcalc/agac062DOI Listing

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