AI Article Synopsis
- - Single biopsies do not accurately capture the diversity within tumors or their changes over time.
- - Research by Bosse et al. highlights the usefulness of sequencing circulating cell-free tumor DNA to track genetic changes in neuroblastoma during treatment with ALK inhibitors.
- - The study also identifies new genetic variants that may drive disease progression when patients are on standard therapies.
Article Abstract
Single biopsies fail to reflect intratumor heterogeneity and tumor evolution. In this issue of Cancer Discovery, Bosse and colleagues show an important role for circulating cell-free tumor DNA sequencing to detect the genomic evolution of neuroblastoma under ALK inhibitor therapy and identify novel (sub)clonal pathogenic variants involved in disease progression under conventional therapy. See related article by Bosse et al., p. 2800 (5).
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| http://dx.doi.org/10.1158/2159-8290.CD-22-1023 | DOI Listing |
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