Background: The prevalence of chronic pain in children and adolescents is high. In some patients, it can be severe and refractory to conventional treatment options. There is increasing interest in the use of cannabinoids for therapeutic purposes in children and adolescents. Nabilone, a synthetic cannabinoid, is approved in Canada for the treatment of nausea and vomiting associated with chemotherapy. It can also be used off label for treatment of chronic pain.
Aims: This study aims to characterize the use of nabilone for severe chronic pain in a pediatric population.
Methods: This is a retrospective cohort study of patients 18 years or younger who were prescribed nabilone for chronic pain in a tertiary multidisciplinary pediatric chronic pain clinic between July 1, 2013, and June 30, 2017.
Results: During the 4-year study period, we screened the charts of 507 patients and identified a total of 28 patients (5.5%) who were treated with nabilone as part of their chronic pain treatment. Common indications for nabilone treatment include mixed neuropathic/nociceptive pain, abdominal pain, neuropathic pain, and spasticity. In all patients, nabilone was prescribed as an adjunctive treatment. Seven patients (25%) reported a slight improvement in pain symptoms. Side effects were reported by 21.4% of patients. The most common reported side effects were sedation and cognitive slowing.
Conclusions: Adjunctive treatment with nabilone may improve pain symptoms in a subset of pediatric chronic pain patients. Further research investigating the long-term safety and efficacy of nabilone in the treatment of chronic pain in children is needed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707533 | PMC |
| http://dx.doi.org/10.1080/24740527.2022.2132138 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Chronic postsurgical pain ICD11 definition is important but not always usable.
Eur J Anaesthesiol
February 2025
From the Anaesthesia and Intensive Care Department, Raymond Poincaré Hospital, APHP, Garches, France; Université Paris-Saclay, UVSQ, Inserm, LPPD, Boulogne, France (VM), Centre for Clinical Studies, University Hospital, Jena (TL), Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster UKM, Munster (EMPZ), Department of Anaesthesiology and Intensive Care, Jena University Hospital Friedrich Schiller University, Jena, Germany (MK, WM), Anaesthesia and Intensive Care Department, Ambroise Paré Hospital, APHP, Boulogne Billancourt (DF) and Université Paris-Saclay, UVSQ, Inserm, LPPD, Boulogne, France (DF).
Chronic pain after surgery = chronic postsurgical pain?
Eur J Anaesthesiol
February 2025
From the Department of Anaesthesiology and Pain Medicine, Bern University Hospital, University of Bern, and the Department of BioMedical Research, University of Bern, Bern, Switzerland (UMS).
Cervical spine infection arising from chronic paronychia: A case report and review of literature.
World J Orthop
December 2024
Department of Orthopedics and Spine Surgery, Guangxi University of Traditional Chinese Medicine Affiliated International Zhuang Hospital, Nanning 530201, Guangxi Zhuang Autonomous Region, China.
Background: Cervical spine pyogenic infection (CSPI) is a rare and challenging form of spinal infection that is typically caused by pyogenic bacteria and primarily affects the cervical vertebral bodies and surrounding tissues. Given its nonspecific symptoms, such as fever and neck pain, early diagnosis is crucial to prevent severe complications, including spinal cord injury. We report a previously unreported case of acute CSPI arising from chronic paronychia, exploring its diagnostic and therapeutic challenges through a review of the current literature.
View Article and Find Full Text PDFConstruction and validation of a risk prediction model for depressive symptoms in a middle-aged and elderly arthritis population.
World J Orthop
December 2024
Department of Orthopedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.
Background: Arthritis is a prevalent and debilitating condition that affects a significant proportion of middle-aged and older adults worldwide. Characterized by chronic pain, inflammation, and joint dysfunction, arthritis can severely impact physical function, quality of life, and mental health. The overall burden of arthritis is further compounded in this population due to its frequent association with depression.
View Article and Find Full Text PDFSerum fatty acid profiles in systemic lupus erythematosus and patient reported outcomes: The Michigan Lupus Epidemiology & Surveillance (MILES) Program.
Front Immunol
January 2025
University of Michigan, Department of Internal Medicine, Ann Arbor, MI, United States.
Introduction: Despite progress in systemic lupus erythematosus (SLE) treatment, challenges persist in medication adherence due to side effects and costs. Precision nutrition, particularly adjusting fatty acid intake, offers a cost-effective strategy for enhancing SLE management. Prior research, including our own, indicates that increased consumption of omega-3 polyunsaturated fatty acids (PUFAs) correlates with improved outcomes in SLE patients.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!