Objective: To determine whether previous (CT) infection among sexually active women is significantly associated with a diagnosis of infertility.
Methods: A prospective descriptive study was conducted in Lleida Health Region (Spain). Women who attended medical consultations for infertility at a public university hospital in 2021 were included in the study. Data were collected during January and February 2022 using the hospital's electronic records and clinical interviews.
Results: The study revealed that having immunoglobulin (Ig)G antibodies for CT was associated with an increased rate of infertility compared to patients with negative titers(p-value < 0.05). Age was also associated with infertility. There was no statistically significant difference among the other characteristics studied, such as previous sexually transmitted infections (STI), previous miscarriages, preliminary cervical lesions, and levels of follicle-stimulating hormone (FSH), estradiol, thyroid-stimulating hormone (TSH), prolactin, and anti-mullerian hormone (p-value > 0.05).
Conclusion: The study showed a high prevalence of infertility among women who had IgG CT antibodies. Although more studies should be conducted, promoting strategies among young women to control this infection may help reduce infertility.
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http://dx.doi.org/10.7759/cureus.30697 | DOI Listing |
BMJ Case Rep
January 2025
Obstetrics and Gynecology; Divison of Reproductive Endocrinology and Infertility, University of Toronto, Toronto, Ontario, Canada
Combined oral contraceptives (COCs) are widely used by reproductive-aged women. Current data suggest that long-term use of COCs can suppress ovarian reserve markers, including anti-mullerian hormone and antral follicle count, which may negatively impact ovarian response and oocyte yield in patients undergoing planned oocyte cryopreservation to preserve future reproductive potential. Discontinuation of COCs can improve ovarian stimulation outcomes, though the ideal duration of cessation is unknown.
View Article and Find Full Text PDFReprod Biomed Online
October 2024
IVF Department, ART Fertility Clinics, Abu Dhabi, UAE.
Research Question: Does a short co-incubation of gametes in conventional IVF affect post-insemination outcomes and embryo morphokinetics?
Design: Sibling oocyte randomized pilot study conducted between December 2020 and March 2023. Eligible couples (n = 55) were women aged 18-43 years with BMI 35 km/m or lower and male normal semen parameters. Cumulus oocyte complexes (COC) (six to 12) were randomized in a 1:1:2 proportion in long (16-18 h) or short (2 h) co-incubation IVF exposure and ICSI, respectively.
Hum Reprod
January 2025
Clinical Experimental Center, Jiangmen Engineering Technology Research Center of Clinical Biobank and Translational Research, Jiangmen Central Hospital, Jiangmen, China.
Study Question: What is the prevalence and trend of infertility among individuals of childbearing age at global, regional, and national levels by sex and socio-demographic index (SDI) across 21 regions and 204 countries and territories?
Summary Answer: Our findings reveal a growing prevalence of infertility among individuals aged 15-49 years worldwide from 1990 to 2021, with an expected continued increase through 2040.
What Is Known Already: Infertility is a persistent global reproductive health issue, leading to significant societal and health consequences. No study has specifically described the current prevalence of infertility, its secular trend, or the variations between regions or countries with different SDI levels.
Int J Gynaecol Obstet
January 2025
Population Services International, Addis Ababa, Ethiopia.
Objective: This study sought to estimate population level prevalence of infertility and explored whether time to pregnancy is related to selected factors.
Methods: This study's analysis was based on data collected from 2081 women who were sampled from participants of the 2016 Ethiopia Demographic and Health Survey based on risk of pregnancy criteria: age between 15 and 49 years, currently married or cohabitating, sexually active, not used contraception method during the 5 years before interview, not menopausal, and not pregnant. We used a current duration (CD) approach in which for each woman we calculated the length of time-at-risk of pregnancy (CD value) in months.
Front Endocrinol (Lausanne)
January 2025
Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Objective: To build a prediction nomogram for early prediction of live birth probabilities according to number of oocytes retrieved in women ≤ 35 years of age.
Methods: A prediction model was built including 9265 infertile women ≤ 35 years of age accepting their first ovum pick-up cycle from January 2018 to December 2022. Least absolute shrinkage and selection operator (LASSO) regression was performed to identify independent predictors and establish a nomogram to predict reproductive outcomes.
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