A regio- and diastereoselective carbometalation of easily accessible CF-substituted cyclopropenes is developed with a diastereoselectivity of the addition opposite to the CF group. This simple strategy allows the preparation of polysubstituted (up to penta-) cyclopropyl rings possessing two adjacent quaternary carbon stereocenters with excellent diastereoselectivities.
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| http://dx.doi.org/10.1021/acs.orglett.2c03714 | DOI Listing |
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