Objective: To provide new evidence on how tonsils surgery in children has geographically varied over time in the context of the Spanish National Health System.
Design: Observational ecological spatiotemporal study on geographical variations in medical practice, using linked administrative datasets, including virtually all surgeries performed from 2003 to 2015.
Setting: The Spanish National Health System, a quasi-federal structure with 17 autonomous communities (ACs), and 203 healthcare areas (HCAs).
Participants: Patients aged 19 and younger residing in the HCAs and ACs.
Interventions: Tonsillectomy with adenoidectomy (T&A); and tonsillectomies alone (T). MAIN ENDPOINTS: (1) Evolution of T&A and T rates; (2) spatiotemporal variation in the risk of receiving T&A or T surgery at regional level (ACs) and HCAs; and (3) the fraction of the variation (FV) attributed to each of the components of variation-ACs, HCAs, year and interaction ACs year.
Results: T&A age-sex standardised rates increased over the period of analysis from 15.2 to 20.9 (5.7 points per 10 000 inhabitants). T alone remained relatively lower than T&A rates, evolving from 3.6 in 2003 to 3.9 in 2015 (0.3 points per 10 000 inhabitants). Most of the risk variation was captured at the HCAs level in both procedures (FV: 55.3% in T&A and 72.5% in T). The ACs level explained 27.6% of the FV in the risk in T&A versus 8% in T. The interaction ACs year was similar in both procedures (FV: 15.5% in T&A and 17.5% in T). The average trend hardly explained 1.46% and 1.83% of the variation, respectively.
Conclusion: Our study showed wide persistent variations with a steady increase in rates and risk of T&A and a stagnation of T alone, where most of the variation risk was explained at HCA level.
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http://dx.doi.org/10.1136/bmjopen-2022-064009 | DOI Listing |
G3 (Bethesda)
March 2025
Institute of Forest Sciences (ICIFOR-INIA), Consejo Superior de Investigaciones Cientificas, 28040 Madrid, Spain.
Stone pine (Pinus pinea L.) is an emblematic tree species within the Mediterranean basin, with high ecological and economic relevance due to the production of edible nuts. Breeding programmes to improve pine nut production started decades ago in Southern Europe but have been hindered by the near absence of polymorphisms in the species genome and the lack of suitable genomic tools.
View Article and Find Full Text PDFObes Surg
March 2025
Addiction Unit, Clinical Institute of Neurosciences (ICN), Hospital Clinic of Barcelona, C/Villarroel, 170, 08036, Barcelona, Spain.
Unlabelled: Following bariatric surgery (BS) patients have an increased risk of alcohol misuse.
Purpose: This 1-year cross-sectional study in potential BS candidates had several objectives: (a) assess the prevalence of risky drinking, alcohol use disorder (AUD), and other substance use/disorder; (b) compare the prevalence of these behaviors to that of the general Spanish population; (c) determine the proportion of patients with positive results in toxicology tests; and (d) study the predictive factors of risky drinking.
Setting: tertiary university hospital.
Basic Res Cardiol
March 2025
Cardiovascular and Metabolic Disorders Programme, Duke-NUS Medical School, 8 College Road, Singapore, Singapore.
Although many cardioprotective interventions have been shown to limit infarct size (IS), in preclinical animal studies of acute myocardial ischemia/reperfusion injury (IRI), their clinical translation to patient benefit has been largely disappointing. A major factor is the lack of rigor and reproducibility in the preclinical studies. To address this, we have established the IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) small animal multisite acute myocardial infarction (AMI) network, with centralized randomization and blinded core laboratory IS analysis, and have validated the network using ischemic preconditioning (IPC).
View Article and Find Full Text PDFDev Psychopathol
March 2025
Psychology, Duke University, Durham, NC, USA.
The present study examined several distinct indicators of regulation (i.e., task-based executive function, surveyed child effortful control, and surveyed household chaos) as moderators of longitudinal bidirectional links between developmental changes in harsh parenting (HP) and child externalizing behaviors (EXT) from age 9 to 14 years.
View Article and Find Full Text PDFEnergy Fuels
March 2025
Environmental Research Group, Instituto de Carboquímica (Spanish National Research Council, ICB-CSIC), Miguel Luesma Castán 4, 50018 Zaragoza, Spain.
In this work, a detailed parametric study of sorption-enhanced methanation (SEM) to produce synthetic natural gas was carried out. A commercial Ni-based catalyst and CaO as a HO sorbent were used as functional materials. The operational parameters studied included the reaction temperature, H/CO module in the feed gas, CO space velocity, and sorbent/catalyst mass ratio.
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