AI Article Synopsis
- The study compared quetiapine levels in whole blood and serum from patients with acute poisoning, using samples from nine patients at a University Hospital.
- Concentrations of quetiapine varied significantly, with whole blood levels ranging from 5.4 to 2780 ng/mL and serum levels from 9.9 to 2500 ng/mL.
- Results indicated that whole blood concentrations may be more reliable than serum concentrations for diagnosing quetiapine poisoning, particularly at higher levels.
Article Abstract
This study aimed to compare whole blood and serum concentrations of quetiapine in acute poisoning cases. Authentic whole blood and respective serum samples were routinely collected from patients diagnosed with blood poisoning at our University Hospital. Accordingly, whole blood and serum paired samples from nine patients (one male and eight female patients) were analyzed for quetiapine using liquid chromatography-mass spectrometry (LC-MS). Quetiapine concentrations in whole blood and serum samples ranged widely from 5.4 to 2780 ng/mL and 9.9 to 2500 ng/mL, respectively. The whole blood/serum concentration ratio was 0.5-1.1 and increased together with an increase in whole blood and serum quetiapine concentrations. The ratio was reversed at around 2500 ng/mL to > 1. Our findings suggest that whole blood concentrations are more useful than serum concentrations in diagnosing quetiapine poisonings.
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| http://dx.doi.org/10.1007/s11419-022-00618-w | DOI Listing |
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