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| http://dx.doi.org/10.4103/ijo.IJO_2162_22 | DOI Listing |
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Background And Objectives: Prostate cancer is the second most frequently diagnosed cancer in men aged 65 years and older globally. The association of prostate cancer with deranged lipid profile and insulin levels is inconsistent and not well understood. This study aimed to analyze the serum levels of lipids, insulin, insulin-like growth factor-1 (IGF-1) and testosterone and to identify their association with the risk of benign prostatic hyperplasia, prostate cancer and its grading.
View Article and Find Full Text PDFCirculating Tumor Cell Count and Overall Survival in Patients With Metastatic Hormone-Sensitive Prostate Cancer.
JAMA Netw Open
October 2024
Huntsman Cancer Institute, University of Utah, Salt Lake City.
Article Synopsis
- In men with metastatic hormone-sensitive prostate cancer (mHSPC), new treatments help many live longer, but how well each person does can be really different.
- Researchers are looking at a blood test that counts tiny cancer cells (CTCs) to see if it can help predict a patient’s survival.
- They studied 503 men to see if the number of CTCs in their blood was linked to how long they lived and how well their treatment worked.
S100A12 inhibits Streptococcus pneumoniae and aids in wound healing of corneal epithelial cells both in vitro and in vivo.
Microbes Infect
September 2024
Prof. Brien Holden Eye Research Centre, LV Prasad Eye Institute, Hyderabad, India; Dr. Chigurupati Nageswara Rao Ocular Pharmacology Research Centre, LV Prasad Eye Institute, Hyderabad, India. Electronic address:
Streptococcus pneumoniae, a leading cause of corneal infections worldwide, are extremely aggressive despite antibiotic sensitivity and exhibit increased resistance towards antibiotics. Antimicrobial peptides are often considered as potent alternatives against antibiotic resistance and here we have investigated the possible roles of S100A12, a host defense peptide, in wound healing and S. pneumoniae infection.
View Article and Find Full Text PDFProbing Short-Range Interactions in Isostructural Hydrate and Perhydrate of Dabrafenib by Magic-Angle Spinning Solid-State NMR.
Anal Chem
July 2024
Tata Institute of Fundamental Research Hyderabad, Hyderabad, Telangana 500046, India.
Dabrafenib (), an anticancer drug, exhibits isostructural properties in its hydrate () and perhydrate () forms, as revealed by single-crystal X-ray diffraction. Despite the HO and HO solvent molecules occupying identical locations, the two polymorphs have different thermal behaviors. In general, determination of stoichiometry of HO in the perhydrate crystals is difficult due to the presence of both HO and HO in the same crystal voids.
View Article and Find Full Text PDFIncidence, management and outcomes in hepatic artery complications after paediatric liver transplantation: protocol of the retrospective, international, multicentre HEPATIC Registry.
BMJ Open
June 2024
Department of Radiology, Medical Imaging Center, University Medical Centre Groningen, Groningen, The Netherlands
Article Synopsis
- Hepatic artery complications (HACs) after pediatric liver transplantation can lead to significant health issues, and this study aims to understand how common they are, how they are managed, and what outcomes arise from these complications.
- The research utilizes the international HEPATIC Registry, collecting data on pediatric patients under 18 who experienced HAC within the last 20 years, focusing on survival rates and treatment success.
- Ethical approval will be obtained from all participating sites, and findings will be shared at conferences and in academic journals, with the study registered on ClinicalTrials.gov (NCT05818644).
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