Three new antibacterial spirooxindole alkaloids, spirobrefeldins A-C (1-3), together with four known analogs, spirotryprostatin M (4), spirotryprostatin G (5), 12β-hydroxyverruculogen TR-2 (6), and 12α-hydroxyverruculogen TR-2 (7), were isolated from terrestrial fungus All the new compounds were elucidated extensively by the interpretation of their NMR (1D and 2D) spectra and high-resolution mass data, and their absolute configurations were determined by computational chemistry and CD spectra. The absolute configurations of spiro carbon C-2 in spirotryprostatin G (5) and spirotryprostatin C in literature were reported as , which were revised to based on experimental and calculated CD spectra. All the compounds were evaluated for their antimicrobial activities toward PAO1, EC1, , , and . Compound 7 displayed moderate inhibitory activity toward dimorphic switch of pathogenic smut fungi at 25 μM. Compounds 3 and 6 showed weak antibacterial activities against phytopathogenic bacterial EC1 at 100 μM.
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| http://dx.doi.org/10.3389/fmicb.2022.1046099 | DOI Listing |
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