AI Article Synopsis
- Sound stimulation, often used for treating tinnitus and hyperacusis, has been shown to change how the central auditory system works after long-term exposure to noise.
- This study focused on the effects of moderate-level noise exposure on auditory processing using CBA/CaJ mice and found that while there was no lasting change in the auditory brainstem response, the acoustic startle response was significantly enhanced.
- Results indicated that low-level noise can improve temporal acuity and affect neural activity in specific parts of the auditory pathway without affecting higher-level auditory nuclei.
Article Abstract
Sound stimulation is generally used for tinnitus and hyperacusis treatment. Recent studies found that long-term noise exposure can change synaptic and firing properties in the central auditory system, which will be detected by the acoustic startle reflex. However, the perceptual consequences of long-term low-intensity sound exposure are indistinct. This study will detect the effects of moderate-level noise exposure (83 dB SPL) on auditory loudness, and temporal processing was evaluated using CBA/CaJ mice. C-Fos staining was used to detect neural activity changes in the central auditory pathway. With two weeks of 83 dB SPL noise exposure (8 hours per day), no persistent threshold shift of the auditory brainstem response (ABR) was identified. On the other hand, noise exposure enhanced the acoustic startle response (ASR) and gap-induced prepulse inhibition significantly (gap-PPI). Low-level noise exposure, according to the findings, can alter temporal acuity. Noise exposure increased the number of c-Fos labeled neurons in the dorsal cochlear nucleus (DCN) and caudal pontine reticular nucleus (PnC) but not at a higher level in the central auditory nuclei. Our results suggested that noise stimulation can change acoustical temporal processing presumably by increasing the excitability of auditory brainstem neurons.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705115 | PMC |
| http://dx.doi.org/10.1155/2022/6463355 | DOI Listing |
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