AI Article Synopsis
- Japanese encephalitis virus (JEV) is a mosquito-borne virus classified in the Flavivirus family, with five different genotypes (G1-G5) based on genetic variations of its envelope protein.
- JEV G3 was previously dominant in Japan but was replaced by G1 in the early 1990s; however, G3 re-emerged in 2004 and was found in swine and cows in Kochi Prefecture in 2018.
- Recent genetic sequencing of JEV isolates shows variations between G3 strains from 2004 and 2018, confirming the presence of both JEV G1 and G3 in the Kochi area.
Article Abstract
Japanese encephalitis virus (JEV) is a mosquito-borne virus belonging to the JEV serocomplex within the genus Flavivirus, family Flaviviridae. It has 5 genotypes, G1-G5, based on the envelope (E) protein nucleotide sequence. JEV G3 circulated in Japan until the early 1990s when it was replaced by G1. JEV G3 was isolated from swine serum samples (sw/Kochi/1/2004) in the Kochi Prefecture, western Japan, in 2004. In addition, the 2018 isolates from pigs and cows (sw/Kochi/492/2018 and bo/Kochi/211/2018) in the same prefecture were identified as G3. The nucleotide sequencing results of the sw/Kochi/492/2018 and bo/Kochi/211/2018 polyprotein region differed from those of the sw/Kochi/1/2004 strain described in our previous report. Seven JEV isolates were identified as G1 in the same geographical area as that in this study. This result indicates that both JEV G1 and G3 are present in the Kochi area.
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| http://dx.doi.org/10.7883/yoken.JJID.2020.941 | DOI Listing |
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