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Neurological Complications Associated With Varicella-Zoster Virus Infection.

Cureus

October 2024

Department of Pediatrics: Pediatric Neurology, Local Healthcare Unit Alto Ave, Guimarães, PRT.

Varicella-zoster virus is a highly contagious infection that primarily affects children. It typically presents as a mild, self-limiting illness with a distinctive rash. However, severe complications can arise, with skin and soft tissue infections being the most common.

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A 75-year-old man presented with cognitive decline, headaches, and ataxic gait. Magnetic resonance imaging (MRI) revealed acute infarcts in multiple brain regions, and vessel wall MRI (VW-MRI) demonstrated concentric arterial wall thickening and enhancement in some intracranial arteries, initially suggesting primary central nervous system vasculitis (PCNSV). Despite immunosuppressive therapy, the patient developed further infarction.

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Clinical Reasoning: A 50-Year-Old Man With Intracerebral Hemorrhage and Tortuous Retinal Arterioles.

Neurology

September 2024

From the Departments of Neurology (J.B., S.W., M.L., A.N.), Genetics (S.W.), and Ophthalmology (M-A. L.), Université Caen-Normandie, CHU de Caen-Normandie, Caen; NeuroDiderot (T.C.), Université Paris Cité, Inserm UMR 1141; and Service de Génétique Moléculaire Neurovasculaire (T.C.), AP-HP, Hôpital Saint-Louis, Paris, France.

A 50-year-old man presented with headache. Examination showed left sided ataxic hemiparesis and elevated blood pressure. Brain imaging revealed an acute intracerebral hemorrhage in the right lentiform nucleus, deep and periventricular white matter hyperintensities, and predominantly deep cerebral microbleeds.

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Article Synopsis
  • Cerebellar hydatid cysts are rare lesions with limited documentation, prompting a systematic review to evaluate diagnostic and management strategies due to their low suspicion index.
  • The review included 15 studies from 1965-2022, primarily from Turkish hospitals, encompassing 12 case reports and three case series, with a mean patient age of 24 years.
  • Common symptoms noted were headaches, ataxic gait, and visual disturbances, and the most frequent treatment involved surgical intervention along with postoperative medication like albendazole and praziquantel.
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This study examines a four-year-and-one-month-old male with no significant past medical, family, or surgical history who initially presented to the pediatric clinic with cough, rhinorrhea, conjunctivitis, emesis, leg and arm pain, and increased difficulty ambulating. The patient was transferred to the emergency department and tested positive for a non-COVID-19 coronavirus infection. The patient was stabilized, given intravenous fluids, and discharged only to return to the clinic the next day with the onset of a headache, right eye ptosis, an inability to bear weight, and bilateral upper and lower extremity weakness resulting in an ataxic gait.

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