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Nanoparticle innovations in targeted cancer therapy: advancements in antibody-drug conjugates.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.
Antibody-drug conjugates (ADCs) have emerged as a promising strategy in targeted cancer therapy, enabling the precise delivery of cytotoxic agents to tumor sites while minimizing systemic toxicity. However, traditional ADCs face significant limitations, including restricted drug loading capacity, where an optimal drug-to-antibody ratio (DAR) is crucial; low DARs may lead to insufficient potency, while high DARs can cause rapid clearance and increased toxicity. Additionally, ADCs often suffer from instability in circulation due to the potential for premature release of cytotoxic agents, resulting in off-target effects and reduced therapeutic efficacy.
View Article and Find Full Text PDFStudy on the linkage mechanism between key strata fracture in overburden and surface subsidence during caving mining in extra-thick coal seams.
Sci Rep
January 2025
Haohua Hongqingliang Mining Company, Ltd, Ordos, 014300, Inner Mongolia, China.
Caving mining in extra-thick coal seams induces large-scale overburden movement, leading to more intense fracture processes in key strata, more significant surface subsidence, and frequent dynamic disasters in mines. This study, using the N34-2 caving face of the 17th coal seam at Junde Mine as a case study, aims to investigate the time-varying linkage mechanism between surface subsidence, microseismic characteristics, and fracture scales of the overburden's key strata under such mining conditions. Based on Timoshenko's theory, a bearing fracture mode for the overburden's key strata is proposed, and corresponding fracture criteria are established.
View Article and Find Full Text PDFPig nasal and rectal microbiotas are involved in the antibody response to Glaesserella parasuis.
Sci Rep
January 2025
Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), 08193, Bellaterra, Barcelona, Spain.
Vaccination stands as one of the most sustainable and promising strategies to control infectious diseases in animal production. Nevertheless, the causes for antibody response variation among individuals are poorly understood. The animal microbiota has been shown to be involved in the correct development and function of the host immunity, including the antibody response.
View Article and Find Full Text PDFIntersection between individual, household, environmental and system level factors in defining risk and resilience for children in Kenya's ASAL: A qualitative study.
PLoS One
January 2025
Institute for Human Development, Aga Khan University, Nairobi, Kenya.
Introduction: Children growing up in arid and semi-arid regions of Sub-Saharan Africa (SSA) face heightened risks, often resulting in poor developmental outcomes. In Kenya, the arid and semi-arid lands (ASAL) exhibit the lowest health and developmental indicators among children. Despite these risks, some children grow up successfully and overcome the challenges.
View Article and Find Full Text PDFLeveraging digital health systems maturity assessments to guide strategic priorities.
J Public Health Afr
December 2024
Department of Global Health, University of Washington, Seattle, United States of America.
Background: Many low- and middle-income countries (LMICs) face the daunting task of digitising, maturing and deciding where to invest in digital health systems.
Aim: Describing the facilitators and barriers to conducting digital health maturity assessments and how health leaders can prioritise the assessments.
Setting: eHealth leaders from 10 African countries, working or supporting Ministries of Health's digital health and participating in the eHealth Leaders' Forum from July 2023 to September 2023.
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