AI Article Synopsis
- Salmonella enterica serovar Enteritidis (S. Enteritidis) can infect chickens and be transmitted to humans, prompting a study on avian resistance mechanisms.
- Researchers crossed two local chicken breeds and tested their resistance by inoculating hybrids with S. Enteritidis at a young age and sampling them afterward.
- The study identified 12 microbial species that thrived in response to S. Enteritidis, suggesting they help maintain intestinal stability in chickens by boosting phenylpropanoid production, which may enhance our understanding of gut microbiota's role in resistance.
Article Abstract
Salmonella enterica serovar Enteritidis (S. Enteritidis) can colonize in the intestinal tract of chickens and transmit to humans. In order to decrypt the mechanism of avian resistance to S. Enteritidis, we utilized two China local chicken breeds to generate the reciprocal crosses (the Cross and the Reverse-cross). The two lines of hybrids were orally inoculated with S. Enteritidis at 2-day old and sampled at 3 days post-inoculation. Along the analysis direction of multi-omics, differential metabolites, functional pathways and correlated microbes, we found that 12 species of microbes thrived upon S. Enteritidis challenge and probably contributed to the intestinal stability in the Cross by enhancing the production of phenylpropanoids. Our findings can help to understand the symbiotic and resistant mechanisms derived from the intestinal microbiota.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803327 | PMC |
| http://dx.doi.org/10.1111/1751-7915.14180 | DOI Listing |
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