AI Article Synopsis

  • The study investigates the effectiveness of Granulocyte colony-stimulating factor (G-CSF) compared to human chorionic gonadotropin (HCG) in improving pregnancy outcomes for women with repeated implantation failure (RIF) undergoing intra-cytoplasmic sperm injection (ICSI).
  • Conducted at Azhar University Hospitals, 100 RIF women were randomly assigned to receive either G-CSF or HCG on embryo transfer day, with both groups showing different clinical outcomes.
  • Results indicated that G-CSF significantly improved implantation rates, chemical pregnancies, and clinical pregnancies when compared to HCG, marking a notable finding in fertility treatments.

Article Abstract

Background: Repeated implantation failure (RIF) is defined as the case whereby the transferred embryos fail to implant after several attempts of In vitro fertilization (IVF) which causes a profound impact on the quality of life and financial burden. Some clinical studies have confirmed that Granulocyte colony-stimulating factor (G-CSF) and human chorionic gonadotropin (HCG) can improve pregnancy outcomes and implantation rates. Hence, our study aims to compare the efficacy of G-CSF and HCG on pregnancy outcomes in RIF women who undergo intra-cytoplasmic sperm injection (ICSI).

Methods: This randomized, single-blinded study was conducted et al.-Azhar University Hospitals, Cairo, Egypt, between 10 October 2020 and 20 December 2020. The study included 100 women aged 20-43 years old undergoing ICSI cycles, with a history of RIF. Patients were divided randomly into two groups: group (1): included 50 patients injected with 500 IU of intrauterine HCG on embryo transfer day, and group (2): Included 50 patients injected with G-CSF on the embryo transfer day.

Results: In 100 RIF women, we found a significant improvement in pregnancy outcomes favoring G-CSF over HCG including implantation rate, chemical pregnancy, and clinical pregnancy (P < 0.0001, P = 0.0003, and P = 0.0006, respectively).

Conclusion: For the first time, we demonstrated a significant improvement in pregnancy outcomes favoring G-CSF over HCG in terms of implantation rate, chemical pregnancy, and clinical pregnancy.

Trial Registration: The study was registered on Pan African Clinical Trials Registry with the following number: PACTR202010482774275 and was approved on 2 October 2020.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706918PMC
http://dx.doi.org/10.1186/s12884-022-05098-9DOI Listing

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