Effects of reaction environments on the structure and physicochemical properties of chitosan and its derivatives.

The structural transformation of chitosan caused by reaction environment is one of the main factors affecting its functional properties. Herein, the effects of homogeneous and heterogeneous reactions on the structure and properties of chitosan were investigated. The pretreatment of reaction increased the deacetylation degree (DD) of chitosan and resulted in its degradation. In contrast, the effect of alkali dissolution process on the above characteristics was less than 8 %. In addition, the modification of functional groups and alkaline reaction environment leaded to further degradation and deacetylation of chitosan. The alkali swelling increased the specific surface area of chitosan particles, but not completely destroy its internal structure to ensure the uniformity of reaction. Interestingly, the homogeneous modification of dissolved chitosan at lower temperature reduced the degree of substitution (DS) of its derivatives but made them exhibit self-assembly properties. This study provided theoretical basis for precise preparation and application of chitosan derivatives.