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Article Synopsis
- The study investigates the challenges of diagnosing and managing cervical lesions in patients with Peutz-Jeghers syndrome (PJS) by analyzing MRI features in relation to pathological types.
- A total of 34 PJS patients were categorized into four groups based on their lesions, revealing significant differences in MRI characteristics, such as lesion extent and microcyst distribution.
- A new grading system was developed from these MRI findings to help assess the potential malignancy of cervical lesions, aiming to improve treatment recommendations and enhance collaboration between healthcare professionals.
Article Synopsis
- Benign male genital pigmentation is often observed in men with male genital lichen sclerosus (MGLSc), but there is a lack of clear terminology and limited research on this topic.
- The study examines 21 patients with MGLSc who have benign penile pigmentation, revealing that most patients reported pigmentation developing after their MGLSc symptoms, and the appearance of these pigmented areas remained stable over time.
- The paper suggests that genital lentiginosis and melanosis may appear similar clinically, but there's a potential risk for penile melanoma in MGLSc patients; hence, it's crucial to approach pigmented lesions with a readiness for biopsy and follow-up.
[Clinicopathological features and prognostic analysis of synchronous mucinous metaplasia and neoplasia of the female genital tract].
Zhonghua Zhong Liu Za Zhi
December 2024
Department of Gynecological Oncology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai200090, China.
Article Synopsis
- Synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN-FGT) is a rare condition studied in 25 cases at Fudan University, focusing on its clinicopathologic characteristics and prognosis from January 2012 to October 2022.
- Most patients were around 46-47 years old, presenting symptoms like irregular vaginal bleeding, pelvic pain, and ovarian cysts; two cases were linked to Peutz-Jeghers syndrome.
- The study found that the cervix was the most affected site, with treatment often involving surgery and sometimes additional therapies, revealing that prognosis was generally good, especially when correlated with factors like disease stage and number of affected sites.
When synchronous mucinous metaplasia and neoplasia of the female genital tract and peutz-jeghers syndrome meet: a case report and literature reviews.
BMC Womens Health
June 2024
College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong, People's Republic of China.
Background: Peutz-Jeghers syndrome (PJS) is characterized by the presence of hamartomatous polyps in the gastrointestinal tract and mucocutaneous pigmentation on the lips, oral mucosa, nose, fingers, and toes. Synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN-FGT) refers to the occurrence of multifocal mucinous lesions in at least two sites, including the cervix, uterus, fallopian tubes, and ovaries, in the female genital tract. SMMN-FGT and PJS are rare diseases with a very low incidence, especially when occurring simultaneously.
View Article and Find Full Text PDFPRAME expression in genital melanocytic lesions - Potential diagnostic pitfall of intermediate expression in atypical genital nevi.
Pathol Res Pract
August 2024
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
Article Synopsis
- The study investigates the use of PRAME immunostaining to diagnose genital melanocytic lesions, including invasive melanoma and atypical genital nevi, reporting that PRAME has shown significant promise in confirming malignancy.
- After analyzing 66 cases, results indicated that invasive melanoma and melanoma-in-situ had much higher PRAME expression compared to atypical genital nevi and other benign lesions, suggesting that PRAME can help differentiate between these conditions.
- However, the findings also caution that low levels of PRAME expression, particularly in atypical genital nevi, should not be seen as conclusive evidence of malignancy, highlighting the need for thorough histological examination.
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