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Beyond the baseline: Quantification of two Phosphatidylethanol (PEth) homologues in Whole Blood by LC-MS/MS and Retrospective Data Analysis from a National Reference Laboratory.
J Anal Toxicol
January 2025
ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories, Salt Lake City, UT, USA.
Unlabelled: Background - Alcohol is the most abused substance in Western society, resulting in major economic losses and negative health consequences. Therefore, there is a need for a selective and robust detection method for alcohol consumption in various clinical and forensic settings. This study aimed to validate a mass spectrometry method for quantifying phosphatidylethanol (PEth) and perform retrospective data analysis from the patient population of a national reference laboratory.
View Article and Find Full Text PDFRegistered Reports in Biopsychosocial Science and Medicine: To Infinity and Beyond.
Psychosom Med
January 2025
From the School School of Psychology, University of Leeds, Leeds, UK.
In April 2023, Psychosomatic Medicine, now renamed Biopsychosocial Science and Medicine, introduced registered reports as a new article format. Registered reports are a type of scientific article in which the research methods and proposed analyses are preregistered and peer-reviewed before the data are collected or analyzed. We were excited to be joining a growing number of journals internationally to offer this format and to be aligning with the Behavioral Medicine Research Council's statement on open science, recognizing the value of publishing registered reports in our field.
View Article and Find Full Text PDFShareable artificial intelligence to extract cancer outcomes from electronic health records for precision oncology research.
Nat Commun
November 2024
Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, USA.
Databases that link molecular data to clinical outcomes can inform precision cancer research into novel prognostic and predictive biomarkers. However, outside of clinical trials, cancer outcomes are typically recorded only in text form within electronic health records (EHRs). Artificial intelligence (AI) models have been trained to extract outcomes from individual EHRs.
View Article and Find Full Text PDFSpecial Issue on Informatics Education: Vanderbilt Clinical Informatics Center Education Strategy: To Infinity and Beyond!
Appl Clin Inform
October 2024
Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, United States.
Background: The Vanderbilt Clinical Informatics Center (VCLIC) is based in the Department of Biomedical Informatics (DBMI) and operates across Vanderbilt University Medical Center (VUMC) and Vanderbilt University (VU) with a goal of enabling and supporting clinical informatics research and practice. VCLIC supports several types of applied clinical informatics teaching, including teaching of students in courses, professional education for staff and faculty throughout VUMC, and workshops and conferences that are open to the public.
Objectives: In this paper, we provide a detailed accounting of our center and institution's methods of educating and training faculty, staff, students, and trainees from across the academic institution and health system on clinical informatics topics, including formal training programs and informal applied learning sessions.
Bupivacaine and liposomal bupivacaine do not produce prolonged perineural anesthesia in a lameness model and are detectable beyond clinical effect in conditioned Thoroughbreds.
Am J Vet Res
November 2024
Department of Large Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, FL.
Objective: To determine (1) the dose of liposomal bupivacaine (LB) to eliminate grade 2 of 5 lameness, the (2) duration of analgesia of LB versus bupivacaine hydrochloride (BH), and (3) LB pharmacokinetics versus BH.
Methods: A reversible lameness model was validated in conditioned Thoroughbred horses (n = 12), aged 3 to 10 years. A dose-response trial compared subjective and objective lameness following abaxial sesamoid block with 25 mg BH/nerve or 30, 60, or 133 mg LB/nerve (n = 3/group).
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