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Low-dose IL-2 reduces IL-21 T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes. | LitMetric

Low-dose IL-2 reduces IL-21 T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes.

Nat Commun

JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.

Published: November 2022

AI Article Synopsis

Article Abstract

Despite early clinical successes, the mechanisms of action of low-dose interleukin-2 (LD-IL-2) immunotherapy remain only partly understood. Here we examine the effects of interval administration of low-dose recombinant IL-2 (iLD-IL-2) in type 1 diabetes using high-resolution single-cell multiomics and flow cytometry on longitudinally-collected peripheral blood samples. Our results confirm that iLD-IL-2 selectively expands thymic-derived FOXP3HELIOS regulatory T cells and CD56 NK cells, and show that the treatment reduces the frequency of IL-21-producing CD4 T cells and of two innate-like mucosal-associated invariant T and VV CD8 T cell subsets. The cellular changes induced by iLD-IL-2 associate with an anti-inflammatory gene expression signature, which remains detectable in all T and NK cell subsets analysed one month after treatment. These findings warrant investigations into the potential longer-term clinical benefits of iLD-IL-2 in immunotherapy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705541PMC
http://dx.doi.org/10.1038/s41467-022-34162-3DOI Listing

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