AI Article Synopsis
- The study evaluated the link between sodium intake (measured through 24-hour sodium excretion) and cardiovascular (CV) events.
- A systematic review included 9 studies with over 645,000 participants, revealing a significant non-linear relationship between sodium excretion and CV risk.
- The findings suggest that a 1 g increase in sodium intake raises the risk of CV events by up to 4%, indicating a need for further research to confirm these results.
Article Abstract
Objective: The relationship between sodium intake and cardiovascular (CV) events remains unconfirmed. Therefore, we carried out a systematic review and dose-response meta-analysis for evaluating the potential impact of 24-hour sodium excretion on CV risk. Besides, 24-hour sodium excretion was used to replace daily sodium diet intake.
Methods: We searched ISI Web of Science, Embase, PubMed, and the Cochrane Library. Our study included cohort studies reporting hazard ratio ( ). The random-effects model was used for summarizing the total relative risks ( s) between the included studies. In addition, the generalized least-squares regression was employed to fit the study model.
Results: A total of 9 studies involving 645,006 participants were included in this study. A significant non-linear relationship was observed between sodium excretion and CV events ( < 0.001). In studies collecting 24-h urine samples, the sodium excretion and CV events risk were associated linearly ( : 1.04; 95% : 1.01, 1.07).
Conclusion: In a linear dose-response manner, every 1 g increase in sodium intake was associated with an increased risk of CV events up to 4%. Further studies are required to validate our conclusions further.
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| http://dx.doi.org/10.3967/bes2022.119 | DOI Listing |
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