AI Article Synopsis
- Radiation-induced intestinal damage (RIID) is a significant health issue, especially linked with nuclear events and radiation therapy, and currently lacks effective treatments.
- The balance of gut microbiota is crucial for intestinal health, and radiation disrupts this balance, lowering beneficial bacteria while increasing harmful ones, which can lead to RIID.
- The review discusses how radiation affects gut microbiota and metabolites, explores the pathological mechanisms of RIID, and summarizes treatment strategies that involve regulating microbiota to mitigate damage.
Article Abstract
Radiation-induced intestinal damage (RIID) is a serious disease with limited effective treatment. Nuclear explosion, nuclear release, nuclear application and especially radiation therapy are all highly likely to cause radioactive intestinal damage. The intestinal microecology is an organic whole with a symbiotic relationship formed by the interaction between a relatively stable microbial community living in the intestinal tract and the host. Imbalance and disorders of intestinal microecology are related to the occurrence and development of multiple systemic diseases, especially intestinal diseases. Increasing evidence indicates that the gut microbiota and its metabolites play an important role in the pathogenesis and prevention of RIID. Radiation leads to gut microbiota imbalance, including a decrease in the number of beneficial bacteria and an increase in the number of harmful bacteria that cause RIID. In this review, we describe the pathological mechanisms of RIID, the changes in intestinal microbiota, the metabolites induced by radiation, and their mechanism in RIID. Finally, the mechanisms of various methods for regulating the microbiota in the treatment of RIID are summarized.
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| http://dx.doi.org/10.1016/j.ecoenv.2022.114341 | DOI Listing |
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