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Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs.
Pharmaceutics
January 2025
Department of Pharmaceutical Bioscience, Translational Drug Discovery and Development, Uppsala University, SE-75124 Uppsala, Sweden.
: N-acetyl-galactosamine small interfering RNAs (GalNAc-siRNA) are an emerging class of drugs due to their durable knockdown of disease-related proteins. Direct conjugation of GalNAc onto the siRNA enables targeted uptake into hepatocytes via GalNAc recognition of the Asialoglycoprotein Receptor (ASGPR). With a transient plasma exposure combined with a prolonged liver half-life, GalNAc-siRNA exhibits distinct disposition characteristics.
View Article and Find Full Text PDFEvaluating ChatGPT-4 for the Interpretation of Images from Several Diagnostic Techniques in Gastroenterology.
J Clin Med
January 2025
Precision Medicine Unit, Department of Gastroenterology, São João University Hospital, Alameda Professor Hernâni Monteiro, 4200-427 Porto, Portugal.
Several artificial intelligence systems based on large language models (LLMs) have been commercially developed, with recent interest in integrating them for clinical questions. Recent versions now include image analysis capacity, but their performance in gastroenterology remains untested. This study assesses ChatGPT-4's performance in interpreting gastroenterology images.
View Article and Find Full Text PDFPhotokinetics of Photothermal Reactions.
Molecules
January 2025
Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK.
Photothermal reactions, involving both photochemical and thermal reaction steps, are the most abundant sequences in photochemistry. The derivation of their rate laws is standardized, but the integration of these rate laws has not yet been achieved. Indeed, the field still lacks integrated rate laws for the description of these reactions' behavior and/or identification of their reaction order.
View Article and Find Full Text PDFProduction of Al Alloys with Kelvin Cells Using the Lost-PLA Technique and Their Mechanical Characterization via Compression Tests.
Materials (Basel)
January 2025
Industrial Engineering Department, University of Rome Tor Vergata, 00133 Rome, Italy.
The mechanical behavior of AA6082 Kelvin cell foams under compressive tests has been investigated in this work. The lost-PLA replication technique, a simple and cheap technique, has been adopted as the production method. Six Al alloy samples have been made and successively subjected to compressive tests in order to examine the mechanical response and the repeatability too.
View Article and Find Full Text PDFEssential Oils as Bioinsecticides Against (Linnaeus, 1767): Evaluating Its Efficacy Under a Practical Framework.
Insects
January 2025
Henkel Ibérica S.A, Research and Development (R&D) Insect Control Department, 08005 Barcelona, Spain.
Concerns about the negative effects of traditional insecticides and increasing insecticide resistance have prompted the exploration of botanical alternatives like essential oils (EOs). The registration of biocides is a mandatory procedure, and some regions have established a special status for compounds that meet specific low-risk criteria, which includes certain EOs. This study aimed to evaluate and compare the efficacy of sixteen EOs, both registered as low-risk biocides and/or standard biocides, against the German cockroach, .
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