AI Article Synopsis
- The inflammatory reflex (IR) is a promising target for treating systemic inflammatory disorders, but traditional activators are often costly and have side effects.
- Recent findings suggest that oral sodium bicarbonate (NaHCO3) could safely and affordably stimulate the IR, but the exact mechanisms of how this happens are still not fully understood.
- The authors highlight the potential of NaHCO3 as an IR activator, review current knowledge of the pathways involved, and propose research directions to better understand its effects and compare it to traditional IR activators.
Article Abstract
Stimulation of the inflammatory reflex (IR) is a promising strategy to treat systemic inflammatory disorders. However, this strategy is hindered by the cost and side effects of traditional IR activators. Recently, oral intake of sodium bicarbonate (NaHCO3) has been suggested to activate the IR, providing a safe and inexpensive alternative. Critically, the mechanisms whereby NaHCO3 might achieve this effect and more broadly the pathways underlying the IR remain poorly understood. Here, we argue that the recognition of NaHCO3 as a potential IR activator presents exciting clinical and research opportunities. To aid this quest, we provide an integrative review of our current knowledge of the neural and cellular pathways mediating the IR and discuss the status of physiological models of IR activation. From this vantage point, we derive testable hypotheses on potential mechanisms whereby NaHCO3 might stimulate the IR and compare NaHCO3 with classic IR activators. Elucidation of these mechanisms will help determine the therapeutic value of NaHCO3 as an IR activator and provide new insights into the IR circuitry.
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| http://dx.doi.org/10.1016/j.phrs.2022.106525 | DOI Listing |
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