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Introduction: Recent literature suggests pain management and sedation in ED patients after rapid sequence intubation are done inconsistently, which impacts patient outcomes negatively. The purpose of this study is to compare rates and timing of post-intubation analgesia and sedation before and after an ED pharmacy practice improvement intervention.
Methods: We conducted a retrospective study of adult ED patients intubated over an 18-month period.
Comparison of Different Doses of Pregabalin to Prevent Succinylcholine-Initiated Fasciculations and Myalgia in Patients Under General Anesthesia: A Randomised Controlled Study.
Cureus
August 2024
Anaesthesiology, Shri B. M. Patil Medical College Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, IND.
Background Succinylcholine (SCh) is the most commonly used muscle relaxant during endotracheal intubation, and it is known to cause fasciculations and postoperative myalgia. Pregabalin is structurally similar to the neurotransmitter gamma-aminobutyric acid (GABA), which is known to reduce SCh-induced fasciculations and myalgia. Materials and methods This study was conducted on patients who underwent surgery under general anesthesia.
View Article and Find Full Text PDFDexmedetomidine for reducing succinylcholine-induced myalgia in patients undergoing electroconvulsive therapy: A randomised controlled trial.
Indian J Anaesth
June 2024
Department of Psychiatry, IMS and SUM Hospital, Bhubaneswar, Odisha, India.
Background And Aim: Electroconvulsive therapy (ECT) is an effective intervention for psychiatric patients. Succinylcholine is considered the drug of choice for muscle relaxation for ECT. Significant adverse effects of succinylcholine include fasciculation and myalgia.
View Article and Find Full Text PDFDetection of the T1640C mutation indicating malignant hyperthermia in dogs.
Vet Med (Praha)
November 2023
Department of Biology and Physiology, University of Veterinary Medicine and Pharmacy in Košice, Košice, Slovak Republic.
Malignant hyperthermia (MH) is a clinical syndrome exhibiting elevation of expired carbon dioxide, hyperthermia, muscle rigidity, rhabdomyolysis, acidosis and hyperkalaemia, as well as cardiac dysrhythmia and renal failure. The syndrome manifests itself as a response to anaesthetic agents, such as e.g.
View Article and Find Full Text PDFComparison of Intubating Conditions with Succinylcholine Versus Rocuronium in the Prehospital Setting.
Prehosp Emerg Care
May 2024
Department of Emergency Medicine, University of Washington, Seattle, Washington USA.
Article Synopsis
- The study analyzed the effects of two neuromuscular blocking agents, succinylcholine and rocuronium, during rapid sequence intubation (RSI) performed by emergency medical services on patients without cardiac arrest.
- Both medications showed similar Cormack-Lehane grades (views during laryngoscopy) and first-attempt success rates, with 84% for succinylcholine and 83% for rocuronium.
- The time from drug administration to the first intubation attempt was shorter for succinylcholine (57 seconds) compared to rocuronium (83 seconds), and peri-intubation hypoxemia rates were comparable for both drugs, around 25% for succinylcholine and
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