AI Article Synopsis
- The case report presents a unique instance of melanotic neuroectodermal tumor of infancy (MNTI) in a 9-month-old girl, who also has tetralogy of Fallot (TOF) and congenital hypothyroidism (CH).
- It was found that a lower dosage of levothyroxine (L-T4) for CH slowed MNTI growth, while the standardized dosage improved thyroid function but led to rapid MNTI progression.
- The study highlights the significant impact of thyroid hormone on MNTI growth and emphasizes the need for careful management of co-existing health issues in pediatric MNTI cases.
Article Abstract
To the best of our knowledge, thus far there are no reported cases of melanotic neuroectodermal tumor of infancy (MNTI) with multiple complications. In this case report, we describe the clinical phenotype of MNTI in a 9-month-old female infant associated with tetralogy of Fallot (TOF), a congenital heart defect, and congenital hypothyroidism (CH). Our study showed that the growth of MNTI was delayed by a lower dosage of levothyroxine (L-T4) that was prescribed to treat CH because of the presence of TOF, a severe congenital heart disease. However, the standardized dosage of L-T4 improved thyroid function but stimulated the rapid growth of MNTI. Our report demonstrated that treatment with L-T4 affects the progression of MNTI. Our findings demonstrated the role of thyroid hormone in MNTI growth and progression. Furthermore, our study suggested that the treatment of co-morbidities in children with MNTI requires careful consideration of their effects on the growth and progression of MNTI.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685797 | PMC |
| http://dx.doi.org/10.3389/fcvm.2022.924538 | DOI Listing |
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