Dynamical systems, which are described by differential equations, can have an enhanced response because of their nonlinearity. As one example, the Duffing oscillator can exhibit multiple stable vibratory states for some external forcing frequencies. Although discrete systems that are described by ordinary differential equations have helped to build fundamental groundwork, further efforts are needed in order to tailor nonlinearity into distributed parameter, continuous systems, which are described by partial differential equations. To modify the nonlinear response of continuous systems, topology optimization can be used to change the shape of the mechanical system. While topology optimization is well-developed for linear systems, less work has been pursued to optimize the nonlinear vibratory response of continuous systems. In this paper, a genetic algorithm implementation of shape optimization for continuous systems is described. The method is very general, with flexible objective functions and very few assumptions; it is applicable to any continuous system. As a case study, a clamped-clamped beam is optimized to have a more nonlinear or less nonlinear vibratory response. This genetic algorithm implementation of shape optimization could provide a tool to improve the performance of many continuous structures, including MEMS sensors, actuators, and macroscale civil structures.
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http://dx.doi.org/10.1016/j.heliyon.2022.e11833 | DOI Listing |
Nurs Leadersh (Tor Ont)
June 2025
Adjunct Professor School of Nursing, Faculty of Health Department of Community Health and Epidemiology, Faculty of Medicine Faculty of Graduate Studies Dalhousie University Halifax, NS.
Introduction: Black nurses are under-represented in the Canadian nursing workforce. A legacy of discrimination and systemic barriers reinforce the under-representation of Black nurses in the nursing workforce throughout the health system.
Objective: The objective of this study was to identify and describe organizational initiatives for the recruitment, retention and advancement of Black nurses in the healthcare system.
Cancer Med
February 2025
Pulmonology and Thoracic Oncology Department, APHP Hôpital Tenon and Sorbonne Université, Paris, France.
Background: Real-world data regarding patients with non-small cell lung cancer (NSCLC) with EGFR exon 20 insertion (ex20ins) mutations receiving mobocertinib are limited. This study describes these patients' characteristics and outcomes.
Methods: A chart review was conducted across three countries (Canada, France, and Hong Kong), abstracting data from eligible patients (NCT05207423).
Viruses
January 2025
Post-Graduate Program in Infectious Diseases, Federal University of Espírito Santo, Vitória 29047-105, Espírito Santo State, Brazil.
Emerging and re-emerging infectious diseases have been frequently reported in Brazil. The Program for Monitoring Emerging Diseases (ProMED) is a virtual system with expert curation for monitoring health events, including those occurring in Brazil. This study aimed to describe the ProMED as a complementary surveillance system for emerging infectious diseases in Brazil.
View Article and Find Full Text PDFPharmaceutics
January 2025
School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK.
This paper presents a comprehensive review of the current literature, clinical trials, and products approved for the delivery of antibiotics to the lungs. While there are many literature reports describing potential delivery systems, few of these have translated into marketed products. Key challenges remaining are the high doses required and, for powder formulations, the ability of the inhaler and powder combination to deliver the dose to the correct portion of the respiratory tract for maximum effect.
View Article and Find Full Text PDFPharmaceutics
January 2025
Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy.
Background/objectives: Although extemporaneous formulations of anticancer drug products for personalized therapy are produced according to Good Hospital Pharmacy Manufacturing Practice, the lack of knowledge about drug stability under clinical conditions limits the second-time use of these highly costly medications in clinical practice. Therefore, the residual compounded drugs are considered waste and a cost item that negatively affects the healthcare system. In the context of the ever-increasing interest of the health system in applying practices in line with personalized medicine and spending review policies, this research aimed to demonstrate the feasibility of incorporating analytical techniques into daily routine practice.
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