A systematic review of [Ga]Ga-DOTA-FAPI-04 and [F]FDG PET/CT in the diagnostic value of malignant tumor bone metastasis.

Objective: This study aims to perform a systemic analysis of [Ga]Ga-DOTA-FAPI-04 positron emission tomography (PET)/computerized tomography (CT) and [F]FDG PET/CT for the diagnosis of malignant tumor bone metastasis based on existing clinical evidence.

Methods: This systematic review followed the guidelines of the Preferred Reporting Project (PRISMA) for systematic reviews and meta-analysis. This is a retrospective study of articles published in PubMed. Embase was searched online from the start of May 2022. The main endpoints were the maximum standardized uptake value and the tumor-to-background ratio to determine the examination performance of [68Ga]Ga-DOTA-FAPI-04 and [F]FDG for bone transfer stoves. Based on the entry and discharge standards, two researchers extracted documents and data and then performed the quality evaluation.

Results: A total of eight studies on the metastasis of malignant tumors on bone were included, which involved 358 patients in the final analysis.

Conclusion: [Ga]Ga-DOTA-FAPI-04 showed better detection performance for bone metastasis. The sensitivity of [Ga]Ga-DOTA-FAPI-04 for the diagnosis of the primary tumor was higher than that of [F]FDG, whereas the specificity of [F]FDG was higher than that of [Ga]Ga-DOTA-FAPI-04. However, further randomized controlled trials and prospective clinical trials are warranted to compare the diagnostic performance of [Ga]Ga-DOTA-FAPI-04 PET/CT and [F]FDG PET/CT.

Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/, identifier (CRD42022313019).