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| http://dx.doi.org/10.3389/fcell.2022.1024761 | DOI Listing |
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Application of autophagy in mesenchymal stem cells.
World J Stem Cells
December 2024
Department of Emergency Medicine, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China.
In this editorial, we have taken an in-depth look at the article published by Wan . The study showed that preconditioning mesenchymal stem cells (MSCs) protected them against programmed cell death, and increased their survival rate and therapeutic potential. Autophagy, a type of programmed cell death, is a major intracellular degradation and recycling pathway that is crucial for maintaining cellular homeostasis, self-renewal, and pluripotency.
View Article and Find Full Text PDFMaintenance of stem cell self-renewal by sex chromosomal zinc-finger transcription factors.
World J Methodol
December 2024
Department of Biology, St. Francis College, Brooklyn, NY 11201, United States.
In this Editorial review, we would like to focus on a very recent discovery showing the global autosomal gene regulation by Y- and inactivated X-chromosomal transcription factors, zinc finger gene on the Y chromosome (ZFY) and zinc finger protein X-linked (ZFX). ZFX and ZFY are both zinc-finger proteins that encode general transcription factors abundant in hematopoietic and embryonic stem cells. Although both proteins are homologs, interestingly, the regulation of self-renewal by these transcriptional factors is almost exclusive to ZFX.
View Article and Find Full Text PDFUnraveling the interplay between inflammation and stem cell mobilization or homing: Implications for tissue repair and therapeutics.
Tzu Chi Med J
September 2024
Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien, Taiwan.
Inflammation and stem cell mobilization or homing play pivotal roles in tissue repair and regeneration. This review explores their intricate interplay, elucidating their collaborative role in maintaining tissue homeostasis and responding to injury or disease. While examining the fundamentals of stem cells, we detail the mechanisms underlying inflammation, including immune cell recruitment and inflammatory mediator release, highlighting their self-renewal and differentiation capabilities.
View Article and Find Full Text PDFFGF2 promotes the expansion of parietal mesothelial progenitor pools and inhibits BMP4-mediated smooth muscle cell differentiation.
Front Cell Dev Biol
September 2024
Columbia Center for Human Development (CCHD), Columbia University Irving Medical Center, New York, NY, United States.
Article Synopsis
- * Researchers developed a strong protocol to culture mesothelial progenitor cells (MPCs) from pig and mouse thorax, discovering that BMP4 aids in differentiation into smooth muscle cells, while FGF2 helps expand the MPC pool but inhibits this differentiation.
- * The study highlighted key signaling pathways involving BMP4, FGF2, and a Wnt activator (CHIR99021) that regulate MPC behaviors, offering insights into potential mechanisms underlying mesothelial cell functions and their role in conditions like mesothelioma.
Hematopoietic and leukemic stem cells homeostasis: the role of bone marrow niche.
Explor Target Antitumor Ther
August 2024
Biobank of Research, IRCCS Azienda Ospedaliera-Universitaria di Bologna Policlinico di S. Orsola, 40138 Bologna, Italy.
The bone marrow microenvironment (BMM) has highly specialized anatomical characteristics that provide a sanctuary place for hematopoietic stem cells (HSCs) that allow appropriate proliferation, maintenance, and self-renewal capacity. Several cell types contribute to the constitution and function of the bone marrow niche. Interestingly, uncovering the secrets of BMM and its interaction with HSCs in health paved the road for research aiming at better understanding the concept of leukemic stem cells (LSCs) and their altered niche.
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