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| http://dx.doi.org/10.3389/fgene.2022.1067443 | DOI Listing |
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Transcription: friend or foe of genome stability.
FEBS Lett
January 2025
Istituto di Genetica Molecolare (IGM) L.L. Cavalli Sforza, CNR, Pavia, Italy.
The 18 Workshop on Recent Issues in Bioanalysis (18 WRIB) took place in San Antonio, TX, USA on May 6-10, 2024. Over 1100 professionals representing pharma/biotech companies, CROs, and multiple regulatory agencies convened to actively discuss the most current topics of interest in bioanalysis. The 18 WRIB included 3 Main Workshops and 7 Specialized Workshops that together spanned 1 week to allow an exhaustive and thorough coverage of all major issues in bioanalysis of biomarkers, immunogenicity, gene therapy, cell therapy and vaccines.
View Article and Find Full Text PDFCell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination.
Biomolecules
January 2025
Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
RAD18 is a conserved eukaryotic E3 ubiquitin ligase that promotes genome stability through multiple pathways. One of these is gap-filling DNA synthesis at active replication forks and in post-replicative DNA. RAD18 also regulates homologous recombination (HR) repair of DNA breaks; however, the current literature describing the contribution of RAD18 to HR in mammalian systems has not reached a consensus.
View Article and Find Full Text PDFUnderstanding disorders of the human nervous system: How fish models reveal disease mechanisms from single molecules to behavior (part 2).
Dev Growth Differ
January 2025
Graduate School of Science and Engineering, Saitama University, Saitama, Japan.
The usefulness of zebrafish for understanding the human nervous system is exemplified by the articles in part 1. The virtual special issue part 2 not only covers more work using this well-established species, but also highlights that other fish species may serve as alternative or more appropriate models, due to unique biological or evolutionary characteristics, to explore genetic and molecular mechanisms of neurological and psychiatric disorders.
View Article and Find Full Text PDF"Path of the Heart" (The BPROAD Study) Addresses Optimal Systolic Blood Pressure for Patients With Diabetes.
J Diabetes
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