We studied the effect of α-adrenoreceptor activation after preliminary I-current blockade on the performance of the Langendorff-isolated rat heart 54 days after modeling myocardial infarction. Stimulation of α-adrenoreceptors against the background of application of I blocker ZD7288 in concentrations of 10 and 10 M decreased myocardial inotropy in isolated rat hearts by 50 and 39% (p<0.05) and increased HR by 20 and 15% (p<0.05), respectively. Activation of α-adrenoreceptors against the background of application of ZD7288 in a concentration of 10 and 10 M led to a decrease in the coronary flow in the isolated rat heart with the model of myocardial infarction by 21% (p<0.05) and 32% (p<0.05), respectively.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1007/s10517-022-05640-x | DOI Listing |
Receptors for the vasoactive adipokine apelin, termed APJ receptors, are G-protein-coupled receptors and are widely expressed throughout the cardiovascular system. APJ receptors can also signal via G-protein-independent pathways, including G-protein-coupled-receptor kinase 2 (GRK2), which inhibits nitric oxide synthase (eNOS) activity and nitric oxide (NO) production in endothelial cells. Apelin causes endothelium-dependent, NO-mediated relaxation of coronary arteries from normotensive animals, but the effects of activating APJ receptor signaling pathways in hypertensive coronary arteries are largely unknown.
View Article and Find Full Text PDFFront Pharmacol
January 2025
The Third Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
Background: The Beclin-1/Bcl-2 complex plays a pivotal role in regulating both autophagy and apoptosis in osteoblasts affected by osteoporosis. This study first investigates whether the Bushen Jianpi Huoxue Formula can enhance the cellular function of osteoblasts. Additionally, it initially explores the functional mechanism of Beclin-1/Bcl-2-related apoptosis.
View Article and Find Full Text PDFNat Prod Res
January 2025
Department of Pharmaceutical Chemistry, M.R. College of Pharmaceutical Sciences and Research, Balisha, India.
We investigated the anti-diabetic effects of the ethyl acetate fraction of and its isolated compounds using both and study models. tests showed that the ethyl acetate part of and its separate compounds had better activity blocking α-glucosidase, α-amylase, and α-lipase. The ethyl acetate fraction and its active constituents, barbaloin and gallic acid, significantly ( < 0.
View Article and Find Full Text PDFHistochem Cell Biol
January 2025
College of Life Sciences, Key Laboratory of Animal Reproduction and Biotechnology in Universities of Shandong, Qingdao Agricultural University, Qingdao, 266109, China.
Skin-derived stem cells (SDSCs) are a subtype of adult stem cells (ASCs) that are widely harvested and exempt from ethical restrictions in clinical applications. These cells possess capabilities for self-renewal, proliferation, and multi-lineage differentiation. Compared to model animals like rats and mice, pigs exhibit greater physiological similarity to humans.
View Article and Find Full Text PDFToxicol Appl Pharmacol
January 2025
Department of Pharmacology, Medical Research and Clinical studies Institute, National Research Centre, (ID: 60014618), Dokki, 12622 Giza, Egypt.
Cisplatin is a widely used chemotherapeutic agent, but its clinical utility is limited by side effects affecting different systems and organs, including hepatotoxicity in some cases. Baicalin, a flavonoid isolated from Scutellaria baicalensis, possesses antioxidant, anti-inflammatory and hepatoprotective properties, but its low bioavailability limits its therapeutic use. This study aimed to investigate whether a nanoemulsion formulation of baicalin could enhance its efficacy against cisplatin-induced hepatic injury in rats.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!