We studied the effect of α-adrenoreceptor activation after preliminary I-current blockade on the performance of the Langendorff-isolated rat heart 54 days after modeling myocardial infarction. Stimulation of α-adrenoreceptors against the background of application of I blocker ZD7288 in concentrations of 10 and 10 M decreased myocardial inotropy in isolated rat hearts by 50 and 39% (p<0.05) and increased HR by 20 and 15% (p<0.05), respectively. Activation of α-adrenoreceptors against the background of application of ZD7288 in a concentration of 10 and 10 M led to a decrease in the coronary flow in the isolated rat heart with the model of myocardial infarction by 21% (p<0.05) and 32% (p<0.05), respectively.

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http://dx.doi.org/10.1007/s10517-022-05640-xDOI Listing

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