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Understanding the local-level variations in seasonality of human respiratory syncytial virus infection: a systematic analysis.
BMC Med
January 2025
Department of Epidemiology, National Vaccine Innovation Platform, School of Public Health, Nanjing Medical University, Nanjing, China.
Background: While previous reports characterised global and regional variations in RSV seasonality, less is known about local variations in RSV seasonal characteristics. This study aimed to understand the local-level variations in RSV seasonality and to explore the role of geographical, meteorological, and socio-demographic factors in explaining these variations.
Methods: We conducted a systematic literature review to identify published studies reporting data on local-level RSV season onset, offset, or duration for at least two local sites.
Uncovering mercury accumulation and the potential for bacterial bioremediation in response to contamination in the Singalila National Park.
Sci Rep
January 2025
Molecular Biology and Tissue Culture Laboratory, Department of Tea Science, University of North Bengal, Siliguri, West Bengal, India.
Several recent investigations into montane regions have reported on excess mercury accumulation in high-altitude forest ecosystems. This study explored the Singalila National Park, located on the Singalila ridge of the Eastern Himalayas, revealing substantial mercury contamination. Particular focus was on Sandakphu (3636 m), the highest peak in West Bengal, India.
View Article and Find Full Text PDFComparison of Pharmacokinetics of Long-Acting Local Analgesics: CPL-01, a Novel Extended-Release Ropivacaine, Demonstrates Consistent and Predictable Exposure Compared with Liposomal Bupivacaine.
Clin Drug Investig
January 2025
Cali Biosciences, US, LLC, San Diego, CA, USA.
Background And Objective: There is a significant medical need for improved long-acting local anesthetics to decrease postsurgical pain and reduce postoperative opioid use. While ropivacaine is considered a safer local anesthetic than bupivacaine, no long-acting ropivacaine formulation is currently marketed. Available formulations of bupivacaine show inconsistent pharmacokinetics (PK) among different surgical models, and inconsistency in PK may lead to a reluctance to use the medication owing to fear of local anesthetic systemic toxicity (LAST) or unreliable efficacy.
View Article and Find Full Text PDFUnderstanding collective behavior in biological systems through potential field mechanisms.
Sci Rep
January 2025
School of Electronics and Information Engineering, University of Science and Technology Liaoning, Anshan, 114051, China.
Collective behavior in biological systems emerges from local interactions among individuals, enabling groups to adapt to dynamic environments. Traditional modeling approaches, such as bottom-up and top-down models, have limitations in accurately representing these complex interactions. We propose a novel potential field mechanism that integrates local interactions and environmental influences to explain collective behavior.
View Article and Find Full Text PDFVirtual hospitals are rapidly being implemented internationally. Research has predominantly focused on clinical outcomes not implementation. We aimed to identify pre-implementation determinants to enable health services to tailor virtual hospital models, increasing likelihood of suitability, acceptability, uptake, clinical effectiveness, and sustainability.
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