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Hepatitis B core-related antigen rapid diagnostic test for point-of-care identification of women at high risk of hepatitis B vertical transmission: a multicountry diagnostic accuracy study.
Lancet Gastroenterol Hepatol
March 2025
Institut Pasteur, Université Paris Cité, Unité d'Épidémiologie des Maladies Émergentes, Paris, France; Pasteur International Unit at Kumamoto University/National Center for Global Health and Medicine, Japan; International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan. Electronic address:
Background: Timely administration of the hepatitis B virus (HBV) birth dose vaccine, along with identifying high-risk pregnant individuals for antiviral prophylaxis, is essential for the global elimination of vertical transmission of HBV. However, in resource-limited settings, access to HBV DNA testing is scarce, and accurate rapid tests for HBeAg are lacking. We aimed to assess the diagnostic performance of a newly developed hepatitis B core-related antigen (HBcrAg) rapid diagnostic test (RDT) to identify women who are HBsAg-positive and eligible for antiviral prophylaxis.
View Article and Find Full Text PDFDiagnostic tests for tuberculosis infection and predictive indicators of disease progression: utilizing host and pathogen biomarkers to enhance the TB elimination strategies.
Int J Infect Dis
March 2025
Translational Research Unit, National Institute for Infectious Diseases "Lazzaro Spallanzani"- Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy. Electronic address:
Tuberculosis (TB) remains the leading cause of death worldwide from a single infectious disease. An estimated quarter of the world's population, about 2 billion people, has an immune response to Mtb without clinical, microbiological, or radiological signs of TB disease. This condition is known as TB infection (TBI) and carries a lifelong risk of reactivation with 5-10% of individuals eventually developing TB disease during their lifetime.
View Article and Find Full Text PDFCost-effectiveness analysis comparing QuantiFERON test and tuberculin skin test for the diagnosis of latent tuberculosis infection in immunocompetent children under 15 years of age in Colombia.
BMJ Open
March 2025
Departamento de Pediatría, Universidad de Antioquia, Medellin, Colombia.
Objective: To determine the cost-effectiveness of the QuantiFERON (QFT) test versus the tuberculin skin test (TST) in diagnosing latent tuberculosis infection (LTBI) in immunocompetent children under 15 years of age who are in contact with active tuberculosis (TB) patients in the context of the Colombian healthcare system.
Design: Health economic evaluation. Decision tree over a horizon of <1 year.
Plant-based Diet and Chronic Kidney Disease: A Systematic Review and Meta-analysis.
J Ren Nutr
March 2025
Department of Health Studies & Applied Educational Psychology, Columbia University, New York, NY, USA, 10027.
Objective: We aimed to perform a systematic review and meta-analyses to evaluate the impact of plant-based diet (PBD) on chronic kidney disease (CKD).
Methods: A systematic search of PubMed and Embase was conducted from inception to August 2023 to evaluate the association between adopting a PBD and the incidence, progression, and mortality of CKD. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using a random-effects model.
Mortality and its influencing factors during anti-tuberculosis treatment in pulmonary tuberculosis patients in Hunan Province.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
October 2024
Department of Prevention and Treatment, Hunan Institute for Tuberculosis Control (Hunan Chest Hospital), Changsha 410013, China.
Objectives: Reducing mortality during anti-tuberculosis treatment is crucial for completing full-course standardized therapy and achieving tuberculosis cure. The study aims to analyze the mortality and its influencing factors among pulmonary tuberculosis patients undergoing anti-tuberculosis treatment in Hunan Province.
Methods: In this retrospective cohort study, data on pulmonary tuberculosis patients from the Hunan Provincial Tuberculosis Management Information System were collected between January 1, 2019 and December 31, 2023.
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