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| http://dx.doi.org/10.1007/s40520-022-02304-8 | DOI Listing |
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Design and Implementation of an Opt-Out, End-to-End, Preemptive Testing Program for Patients Planned for a Systemic Fluoropyrimidine.
JCO Oncol Pract
August 2024
Dana-Farber Cancer, Boston, MA.
Purpose: Several allelic variants of the gene encoding dihydropyrimidine dehydrogenase (DPD) are associated with impaired metabolism of the systemic fluoropyrimidine fluorouracil (5FU) and its oral prodrug, capecitabine, which elevates the risk for severe toxicity. Following a patient death related to capecitabine toxicity in which DPD deficiency was suspected, a multidisciplinary advisory panel was convened to develop an institution-wide approach to future patients planned for a systemic fluoropyrimidine.
Methods: The panel selected an opt-out testing strategy which focused on developing reliable processes to collect and report test results and targeted education.
Impact of Opt-Out Therapy Appointments on Resident Physicians' Mental Health, Well-Being, Stigma, and Willingness to Engage.
J Grad Med Educ
December 2023
is Associate Professor, Department of Internal Medicine, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, Utah, USA.
Health care professionals report higher levels of mental health symptoms, pandemic-related stress, personal health concerns, and reduced proactive coping, especially in recent years marked by the COVID-19 pandemic. As physician utilization rates of mental health and well-being services remain low, the need for preemptive care is crucial. The present study sought to ascertain satisfaction, value, and attitude toward future mental health services among resident physicians.
View Article and Find Full Text PDFOverview of trials on artificial intelligence algorithms in breast cancer screening - A roadmap for international evaluation and implementation.
Eur J Radiol
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Department of Radiology, University of Cambridge School of Clinical Medicine, Box 218, Level 5, Cambridge Biomedical Campus, Cambridge CB2 0QQ, United Kingdom; Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, United Kingdom. Electronic address:
Accumulating evidence from retrospective studies demonstrate at least non-inferior performance when using AI algorithms with different strategies versus double-reading in mammography screening. In addition, AI algorithms for mammography screening can reduce work load by moving to single human reading. Prospective trials are essential to avoid unintended adverse consequences before incorporation of AI algorithms into UK's National Health Service (NHS) Breast Screening Programme (BSP).
View Article and Find Full Text PDFWhen to opt for preemptive anticoagulation with SARS-CoV-2 infection in the long-term care facilities.
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Division of Geriatrics and Palliative Care, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Embedded point of care randomisation for evaluating comparative effectiveness questions: PROSPECTOR-critical care feasibility study protocol.
BMJ Open
September 2022
Institute of Health Informatics, University College London, London, UK.
Introduction: Many routinely administered treatments lack evidence as to their effectiveness. When treatments lack evidence, patients receive varying care based on the preferences of clinicians. Standard randomised controlled trials are unsuited to comparisons of different routine treatment strategies, and there remains little economic incentive for change.
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