Hydrogels and biological cartilage tissues are highly similar in structure and composition due to their unique characteristics such as high-water content and low friction coefficients. The introduction of hydrogel cartilage can effectively reduce the friction coefficient and wear coefficient of the original bone joint and the implanted metal bone joint (generally titanium alloy or stainless steel), which is considered as a perfect replacement material for artificial articular cartilage. How to accurately regulate the local tribological characteristics of hydrogel artificial cartilage according to patient weight and bone shape is one of the important challenges in the current clinical application field of medical hydrogels. In this study, the mechanism by which micro-pits improve the surface friction properties was studied. Ultraviolet lasers were used to efficiently construct micro-pits with different shapes on a polyvinyl alcohol hydrogel in one step. It was shown that by using such a maskless laser processing, the performance of each part of the artificial cartilage can be customized flexibly and effectively. We envision that the approach demonstrated in this article will provide an important idea for the development of a high-performance, continuous and accurate method for controlling surface friction properties of artificial cartilage.
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http://dx.doi.org/10.3390/nano12224103 | DOI Listing |
Bioengineering (Basel)
January 2025
Department of Pathology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602, USA.
Three-dimensional printing was introduced in the 1980s, though bioprinting started developing a few years later. Today, 3D bioprinting is making inroads in medical fields, including the production of biomedical supplies intended for internal use, such as biodegradable staples. Medical bioprinting enables versatility and flexibility on demand and is able to modify and individualize production using several established printing methods.
View Article and Find Full Text PDFJ Orthop Surg Res
January 2025
Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Background: Osteoarthritis (OA), characterized by progressive degeneration of cartilage and reactive proliferation of subchondral bone, stands as a prevalent condition in orthopedic clinics. However, the precise mechanisms underlying OA pathogenesis remain inadequately explored.
Methods: In this study, Random Forest (RF), Least Absolute Shrinkage and Selection Operator (LASSO), and Support Vector Machine-Recursive Feature Elimination (SVM-RFE) machine learning techniques were employed to identify hub genes.
J Vet Intern Med
January 2025
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Background: Clinical characteristics of cervical hydrated nucleus pulposus extrusion (HNPE) in dogs compared to other causes of cervical myelopathy are not well described.
Hypothesis/objectives: To evaluate for clinical characteristics and mechanical ventilation likelihood associated with HNPE compared to other causes of cervical myelopathy.
Animals: Three hundred seventy-seven client-owned dogs from 2010 to 2022.
Mater Today Bio
February 2025
Department of Orthopedics, the Fourth Medical Center of PLA General Hospital, Beijing, 100048, PR China.
A meniscus injury is a common cartilage disease of the knee joint. Despite the availability of various methods for the treatment of meniscal injuries, the poor regenerative capacity of the meniscus often necessitates resection, leading to the accelerated progression of osteoarthritis. Advances in tissue engineering have introduced meniscal tissue engineering as a potential treatment option.
View Article and Find Full Text PDFSci Rep
January 2025
Biomedical Engineering Department, Faculty of Engineering, Helwan University, Cairo, Egypt.
Car accidents, infections caused by bacteria or viruses, metastatic lesions, tumors, and malignancies are the most frequent causes of chest wall damage, leading to the removal of the affected area. After excision, artificial bone or synthetic materials are used in chest wall reconstruction to restore the skeletal structure of the chest. Chest implants have traditionally been made from metallic materials like titanium alloys due to their biocompatibility and durability.
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