AI Article Synopsis
- A new method has been developed for synthesizing cyclopropyl carbaldehydes and ketones from 2-hydroxycyclobutanones and aryl thiols, allowing for continuous flow and scalability.
- The process uses Amberlyst-35 as a reusable catalyst and is carried out under mild conditions, making it efficient for multigram production.
- Various oxidation reactions demonstrate the synthetic potential of the resulting compounds, leading to a range of derivatives such as sulfoxides, sulfones, and carboxylic acids.
Article Abstract
The straightforward, continuous-flow synthesis of cyclopropyl carbaldehydes and ketones has been developed starting from 2-hydroxycyclobutanones and aryl thiols. This acid-catalyzed mediated procedure allows access to the multigram and easily scalable synthesis of cyclopropyl adducts under mild conditions, using reusable Amberlyst-35 as a catalyst. The resins, suitably ground and used for filling steel columns, have been characterized via TGA, ATR, SEM and BET analyses to describe the physical-chemical properties of the packed bed and the continuous-flow system in detail. To highlight the synthetic versatility of the arylthiocyclopropyl carbonyl compounds, a series of selective oxidation reactions have been performed to access sulfoxide and sulfone carbaldehyde cyclopropanes, oxiranes and carboxylic acid derivatives.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699303 | PMC |
| http://dx.doi.org/10.3390/molecules27227943 | DOI Listing |
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