AI Article Synopsis
Article Abstract
This study presents the kinetic modeling of the natural long-term aging of the pharmaceutical substance as well as the intact tablets of Diclofenac. Datasets are collections of near-infrared spectra acquired from the intact tablets packed in plastic blisters and the spectra of the pure substance. Fresh samples and samples at different stages of degradation are analyzed. No methods of accelerated aging were applied. Multi-step application of MCR-ALS in its soft version followed by the kinetic modeling of the results helps to propose a generic degradation mechanism; which includes: a global kinetic model; approximations of the NIR spectra of the intermediate and product; rough estimates of rate constants. We study tablets in blister packs; exactly as they are presented in pharmacies; and this is important from a practical point of view.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699027 | PMC |
| http://dx.doi.org/10.3390/molecules27227904 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Divergent brain solute clearance in rat models of cerebral amyloid angiopathy and Alzheimer's disease.
iScience
December 2024
Department of Anesthesiology, Yale School of Medicine, New Haven, CT 06510, USA.
Brain waste clearance from the interstitial fluid environment is challenging to measure, which has contributed to controversy regarding the significance of glymphatic transport impairment for neurodegenerative processes. Dynamic contrast enhanced MRI (DCE-MRI) with cerebrospinal fluid administration of Gd-tagged tracers is often used to assess glymphatic system function. We previously quantified glymphatic transport from DCE-MRI data utilizing regularized optimal mass transport (rOMT) analysis, however, information specific to glymphatic clearance was not directly derived.
View Article and Find Full Text PDFIodine Activation from Iodate Reduction in Aqueous Films via Photocatalyzed and Dark Reactions.
ACS Earth Space Chem
December 2024
Department of Chemistry, University of Colorado Boulder Boulder, Colorado 80309, United States.
Iodine in the atmosphere destroys ozone and can nucleate particles by formation of iodic acid, HIO. Recent field observations suggest iodate recycles from particles sustaining significant gas-phase IO radical concentrations (0.06 pptv) in aged stratospheric air, and in elevated dust plumes.
View Article and Find Full Text PDFEfficient magnetic adsorption of polystyrene nanoplastic from aqueous solutions by eco-friendly FeO nanoparticles: Removal, kinetic and isotherm modeling studies.
J Environ Health Sci Eng
June 2025
Department of Chemistry, Ondokuz Mayis University, Samsun, Turkey.
Unlabelled: Today, nanoplastics (NPs) are a growing environmental concern due to their persistence and widespread distribution, posing risks to ecosystems and human health. Their ability to transport pollutants makes them particularly dangerous, underscoring the urgent need for effective removal methods. Herein, we report the synthesis of an environmentally friendly material that enables the magnetic removal of polystyrene nanoparticles (PSNPs) from aqueous solutions by green chemistry approach.
View Article and Find Full Text PDFSynthesis and biological assessment of benzimidazole-acrylonitrile-1,2,3-triazole derivatives as α-glucosidase inhibitors.
Bioorg Chem
December 2024
Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Persian Medicine, School of Medicine, Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:
In the pursuit of developing potent α-glucosidase inhibitors for managing diabetes, a series of novel benzimidazole-acrylonitrile-1,2,3-triazole derivatives were designed. Sixteen derivatives (12a-p) were synthesized by varying substituents on the phenyl ring of the N-phenylacetamide moiety. Among these, compound 12m emerged as highly effective against α-glucosidase, displaying an IC value of 6.
View Article and Find Full Text PDFInsight into Robust Anion Coordination Behavior of Organic Cathode with Dual Elongated π-Conjugated Motifs.
Angew Chem Int Ed Engl
December 2024
Shenzhen institute of advanced technology Chinese Academy of Sciences, Functional Thin Films Research Centre, 1068 Xueyuan Avenue, Shenzhen University Town, 518000, SHENZHEN, CHINA.
Organics electrode materials offer multi-electron reactivity, flexible structures, and redox reversibility, but encounter poor conductivity and durability in electrolytes. To overcome above barriers, we propose a dual elongation strategy of π-conjugated motifs with active sites, involving extended carbazole and electropolymerized crosslinked polymer, which enhances electronic conductivity by the electronic delocalization of electron-withdrawing conjugated groups, boosts theoretical capacity by increasing redox-active site density, and endows robust electrochemical stability attributed to crosslinked organic structures. As a proof-of-concept, 5,11-dihydridoindolo[3,2-b]carbazole (DHIC) is selected as the model cathode material for a dual-ion battery, with elongated carbazole groups functioning both as redox-active centers and polymerization anchors.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!