AI Article Synopsis
- Novel derivatives of 6-methyluracil and 2,4-quinazoline-2,4-dione were created by adding benzoate groups in polymethylene chains connected to the nitrogen atoms of the pyrimidine ring.
- The variations included different lengths of polymethylene chains (from tri- to hexamethylene) and different substituents on the benzene rings, such as esters and salts.
- Biological tests showed these compounds effectively reduced β-amyloid plaques and showed promise for treating memory issues in a model of Alzheimer's disease.
Article Abstract
Novel derivatives based on 6-methyluracil and condensed uracil, 2,4-quinazoline-2,4-dione, were synthesized with terminal - and -benzoate moieties in polymethylene chains at the N atoms of the pyrimidine ring. In the synthesized compounds, the polymethylene chains were varied from having tris- to hexamethylene chains and quaternary ammonium groups; varying substituents (ester, salt, acid) at benzene ring were introduced into the chains and benzoate moieties. In vivo biological experiments demonstrated the potency of these compounds in decreasing the number of β-amyloid plaques and their suitability for the treatment of memory impairment in a transgenic model of Alzheimer's disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694926 | PMC |
| http://dx.doi.org/10.3390/molecules27227855 | DOI Listing |
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