AI Article Synopsis
- Breast cancer is the most prevalent cancer among women globally, with metastasis being the primary cause of related deaths.
- Despite extensive research, the underlying molecular mechanisms of breast cancer metastasis remain unclear, indicating a need for improved diagnosis and prognosis.
- Exosomes, which are small vesicles secreted by cells, are increasingly recognized for their significant role in cancer metastasis, particularly in breast cancer, leading to potential new strategies for diagnosis and treatment.
Article Abstract
Breast cancer has been the most common cancer in women worldwide, and metastasis is the leading cause of death from breast cancer. Even though the study of breast cancer metastasis has been extensively carried out, the molecular mechanism is still not fully understood, and diagnosis and prognosis need to be improved. Breast cancer metastasis is a complicated process involving multiple physiological changes, and lung, brain, bone and liver are the main metastatic targets. Exosomes are membrane-bound extracellular vesicles that contain secreted cellular constitutes. The biogenesis and functions of exosomes in cancer have been intensively studied, and mounting studies have indicated that exosomes play a crucial role in cancer metastasis. In this review, we summarize recent findings on the role of breast cancer-derived exosomes in metastasis organotropism and discuss the potential promising clinical applications of targeting exosomes as novel strategies for breast cancer diagnosis and therapy.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693078 | PMC |
| http://dx.doi.org/10.3390/ijms232213993 | DOI Listing |
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