AI Article Synopsis

  • The study compares the effectiveness of two chemotherapy regimens, S-1 + cisplatin (SP) and capecitabine + cisplatin (XP), in treating different types of tumors.
  • Data from three phase II trials involving 162 patients revealed that while overall response rates (ORR) were similar between the two treatments, differentiated tumors had better overall survival (OS) with SP, showing more significant tumor shrinkage.
  • For undifferentiated tumors, SP also showed improved OS and progression-free survival (PFS), suggesting that the efficiency of the treatments varies based on tumor histology, with SP generally outperforming XP.

Article Abstract

It has been suggested that the therapeutic efficacy of S-1 + cisplatin (SP) and capecitabine + cisplatin (XP) may differ depending on the histology of the tumor, but no clear evidence exists. Individual participant data were obtained from three randomized phase II trials in which such patients received either SP (S-1 [40-60 mg twice daily for 21 days] plus cisplatin [60 mg/m on day 8], every 5 weeks) or XP (capecitabine [1000 mg/m twice daily for 14 days] plus cisplatin [80 mg/m on day 1], every 3 weeks). A total of 162 patients were included, with 79 patients in the SP arm and 83 patients in the XP arm. Although there was also no difference between arms in ORR according to histological classification, differentiated tumors showed a significantly better OS (but not PFS) for SP versus XP that was associated with a deeper tumor shrinkage. Undifferentiated tumors showed a consistently better OS, and PFS for SP versus XP, likely because cases without tumor shrinkage tended to be fewer for SP. Our data thus showed that SP was superior to XP in this setting, but there were qualitative differences in therapeutic efficacy dependent on tumor histology.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688851PMC
http://dx.doi.org/10.3390/cancers14225673DOI Listing

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