The treatment of middle ear cholesteatoma requires surgical treatment and the reconstruction of the temporal bone, which represents an ongoing problem. Otologists have focused on the research of materials allowing an airy middle ear and the preservation of hearing function to reconstruct the temporal bone. This study evaluated the effect of cyclosporin A (CsA) and a combined biomaterial in the healing process of postoperative temporal bone defects in an animal model. Cultured human Bone Marrow Mesenchymal Stromal Cells (hBM-MSCs) were mixed with hydroxyapatite (Cem-Ostetic), and subsequently applied as a bone substitute after middle ear surgery, showing that the therapeutic potential of hBM-MSCs associated with bone regeneration and replacement is directly influenced by CsA, confirming that it promotes the survival of MSCs in vivo. The therapeutic efficacy of the combination of MSCs with CsA is greater than the sole application of MSCs in a hydroxyapatite carrier. The reconstruction of a temporal bone defect using hBM-MSCs requires an immunosuppressant to improve the results of treatment.
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http://dx.doi.org/10.3390/biomedicines10112918 | DOI Listing |
Korean J Pain
December 2024
School of Anesthesia, Shanxi Medical University, Shanxi, China.
Background: Diabetic pain patients have increased pain at night. Exosomes can relieve neuropathic pain. This study aimed to investigate the efficacy of exosome administration at different time points in relieving diabetic neuropathic pain (DNP) in rats.
View Article and Find Full Text PDFJ Oral Maxillofac Surg
December 2024
Assistant Professor, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA; Assistant Professor, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA. Electronic address:
Background: Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) is a genetic disorder, marked by bone lesions, often affecting the craniofacial skeleton. Pain is a prevalent yet heterogeneous symptom reported by patients with craniofacial FD. Effective treatments are currently lacking, posing a significant clinical challenge to patient care.
View Article and Find Full Text PDFInt J Pediatr Otorhinolaryngol
December 2024
Department of Otolaryngology, Marqués de Valdecilla University Hospital, Santander, Spain; Institute of Research Valdecilla (IDIVAL), Santander, Spain; Department of Medical and Surgical Sciences, University of Cantabria, Santander, Spain.
Objective: Acute mastoiditis, the most common complication of acute otitis media, is approached in our study, focused on children from the Autonomous Community of Cantabria, Spain. The aim is to analyze its clinical-epidemiological characteristics and propose diagnostic and treatment recommendations.
Study Design/setting: We conducted a 30-year retrospective study on patients under 18 years of age diagnosed with acute mastoiditis in Cantabria.
Neuroradiology
December 2024
Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Background And Purpose: Craniosynostoses are rare congenital craniofacial malformations, variably affected by hearing loss, often requiring repeated CT examinations to assess skull or temporal bone (TB) abnormalities. In order to avoid radiation exposure in these young patients, efforts are made to assess the skull abnormalities on MR bone imaging sequences, such as Black Bone (BB). Our aim is to compare BB, a radiation-free imaging technique, with CT for the assessment of the TB.
View Article and Find Full Text PDFCureus
November 2024
Radiology, University of Texas Medical Branch, Galveston, USA.
Based on the available literature, duplicated internal auditory canals (DIACs) represent an exceedingly rare temporal bone anomaly that can result in sensorineural hearing loss (SNHL) in the pediatric population. Often associated with a hypoplastic or aplastic cochlear nerve, DIAC poses limitations on treatment options, such as cochlear implants, for affected patients. Accurate diagnosis and optimal management necessitate a thorough assessment of inner ear structures and potential neural abnormalities with high-resolution computed tomography and magnetic resonance imaging of the temporal bones.
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